Alopecia Areata: A Comprehensive Review of Pathogenesis and Management

    July 2017 in “ Clinical Reviews in Allergy & Immunology ”
    Ralph M. Trüeb, Maria Fernanda Reis Gavazzoni Dias
    Studysummary This review noted that alopecia areata is an autoimmune disease impacting hair follicles and offered insights into its complex pathogenesis involving immune responses, while highlighting ongoing research into new treatments such as Janus kinase inhibitors and other immunomodulatory drugs.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 75

    1. Changes of Serum Trace Elements Level in Patients with Alopecia Areata: A Meta-Analysis Journal of dermatology · 2017
    2. Unsuccessful Treatment of Alopecia Areata with Simvastatin/Ezetimibe: Experience in 12 Patients Skin appendage disorders · 2017
    3. Tofacitinib for the Treatment of Alopecia Areata and Variants in Adolescents Journal of the American Academy of Dermatology · 2016
    4. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016
    5. Estimated Serum Vitamin D Status, Vitamin D Intake, and Risk of Incident Alopecia Areata Among US Women Archives of Dermatological Research · 2016
    6. Genomewide Analysis of Copy Number Variants in Alopecia Areata in a Central European Cohort Reveals Association with MCHR2 Experimental Dermatology · 2016
    7. Familial Aggregation of Alopecia Areata Journal of the American Academy of Dermatology · 2016
    8. Transient Efficacy of Tofacitinib in Alopecia Areata Universalis Case Reports in Dermatology · 2016
    9. A Systematic Review of Pulse Steroid Therapy for Alopecia Areata Journal of the American Academy of Dermatology · 2016
    10. Intralesional Triamcinolone Acetonide Versus Topical Betamethasone Valerate in the Management of Localized Alopecia Areata PubMed · 2015
    11. Clinical Efficacy of Diphenylcyclopropenone in Alopecia Areata: Retrospective Data Analysis of 50 Patients ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2015
    12. Benefit of Different Concentrations of Intralesional Triamcinolone Acetonide in Alopecia Areata: An Intrasubject Pilot Study Journal of the American Academy of Dermatology · 2015
    13. Evaluation of Serum Zinc Level in Patients With Newly Diagnosed and Resistant Alopecia Areata International Journal of Dermatology · 2015
    14. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015
    15. Comparison of High-Dose Corticosteroid Pulse Therapy and Combination Therapy Using Oral Cyclosporine with Low-Dose Corticosteroid in Severe Alopecia Areata Annals of dermatology/Annals of Dermatology · 2015
    16. Hair and Scalp Manifestations in Secondary Syphilis: Epidemiology, Clinical Features and Trichoscopy Dermatology · 2015
    17. Investigation of Oxidative Stress in Patients with Alopecia Areata and Its Relationship with Disease Severity, Duration, Recurrence, and Pattern Clinical and experimental dermatology · 2014
    18. Emerging Treatments in Alopecia Expert Opinion on Emerging Drugs · 2014
    19. Inhibiting Janus Kinases to Treat Alopecia Areata Nature medicine · 2014
    20. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    21. Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis Journal of Investigative Dermatology · 2014
    22. Vitamin D Deficiency in Alopecia Areata British journal of dermatology/British journal of dermatology, Supplement · 2014
    23. The Role of Hair Follicle Immune Privilege Collapse in Alopecia Areata: Status and Perspectives Journal of Investigative Dermatology Symposium Proceedings · 2013
    24. Oxidative Stress in Alopecia Areata: A Case-Control Study American Journal of Clinical Dermatology · 2013
    25. A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata British Journal of Dermatology · 2013
    26. Reduced Level of 25-Hydroxyvitamin D in Chronic/Relapsing Alopecia Areata Dermato-endocrinology · 2013
    27. Bone Mineral Density in Patients with Alopecia Areata Treated with Long-Term Intralesional Corticosteroids PubMed · 2013
    28. Alopecia Areata - Vitiligo Overlap Syndrome: An Emerging Clinical Variant Indian Journal of Dermatology Venereology and Leprology · 2013
    29. Severe Onycholysis in a Card Illusionist with Alopecia Areata Universalis International Journal of Trichology · 2013
    30. Vitamin D Concentrations Are Decreased in Patients with Alopecia Areata Vitamins & Trace Elements · 2012
    31. Prognostic Factors in Methylprednisolone Pulse Therapy for Alopecia Areata Journal of dermatology · 2011
    32. Alopecia Areata: Clinical Presentation, Diagnosis, and Unusual Cases Dermatologic Therapy · 2011
    33. Psoriatic Alopecia/Alopecia Areata–Like Reactions Secondary to Anti–Tumor Necrosis Factor-α Therapy: A Novel Cause of Noncicatricial Alopecia The American Journal of Dermatopathology · 2011
    34. Randomized Comparison of Topical Betamethasone Valerate Foam, Intralesional Triamcinolone Acetonide, and Tacrolimus Ointment in Management of Localized Alopecia Areata International journal of trichology · 2011
    35. Involvement of Scalp and Nails in Lupus Erythematosus Lupus · 2010
    36. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    37. Alopecia Areata Incognita: A Hypothesis Dermatology · 2009
    38. Five-Year Experience in the Treatment of Alopecia Areata with Diphencyprone JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2009
    39. Marie Antoinette Syndrome Archives of Dermatology · 2009
    40. The Therapeutic Effect and Changed Serum Zinc Level After Zinc Supplementation in Alopecia Areata Patients with Low Serum Zinc Level Annals of Dermatology · 2009
    41. Seasonality of Hair Shedding in Healthy Women Complaining of Hair Loss Dermatology · 2009
    42. Alopecia Areata Following Adalimumab Journal of Cutaneous Medicine and Surgery · 2009
    43. Acute Diffuse And Total Alopecia: A New Subtype Of Alopecia Areata With A Favorable Prognosis Journal of The American Academy of Dermatology · 2008
    44. Clinical Significance of Dermoscopy in Alopecia Areata: Analysis of 300 Cases International Journal of Dermatology · 2008
    45. Interventions for Alopecia Areata Cochrane library · 2008
    46. Treatment of Severe Alopecia Areata: Combination Therapy Using Systemic Cyclosporine A with Low Dose Corticosteroids Annals of Dermatology · 2008
    47. Genomewide Scan for Linkage Reveals Evidence of Several Susceptibility Loci for Alopecia Areata The American Journal of Human Genetics · 2007
    48. Development of Alopecia Areata Universalis in a Patient Receiving Adalimumab Archives of dermatology · 2006
    49. Efficacy And Safety Of A New Clobetasol Propionate 0.05% Foam In Alopecia Areata: A Randomized, Double-Blind Placebo-Controlled Trial Journal of the European Academy of Dermatology and Venereology · 2006
    50. Twice Weekly 5 mg Betamethasone Oral Pulse Therapy in the Treatment of Alopecia Areata Journal of the European Academy of Dermatology and Venereology · 2006
    51. Intralesional Treatment of Alopecia Areata with Triamcinolone Acetonide by Jet Injector British Journal of Dermatology · 2006
    52. Topical Immunotherapy of Severe Alopecia Areata with Diphenylcyclopropenone: Experience in an Iranian Population BMC dermatology · 2005
    53. Placebo-Controlled Oral Pulse Prednisolone Therapy in Alopecia Areata Journal of the American Academy of Dermatology · 2005
    54. Decreased Serum Ferritin Is Associated With Alopecia in Women Journal of Investigative Dermatology · 2003
    55. Characterization of Hair Follicle Antigens Targeted by the Anti-Hair Follicle Immune Response Journal of Investigative Dermatology Symposium Proceedings · 2003
    56. Clobetasol Propionate 0.05% Under Occlusion in the Treatment of Alopecia Totalis/Universalis Journal of the American Academy of Dermatology · 2003
    57. Acute Diffuse and Total Alopecia of the Female Scalp: A New Subtype of Diffuse Alopecia Areata That Has a Favorable Prognosis – A Reply Dermatology · 2003
    58. The Pattern and Profile of Alopecia Areata in Singapore: A Study of 219 Asians International Journal of Dermatology · 2002
    59. Acute Diffuse and Total Alopecia of the Female Scalp Dermatology · 2002
    60. Alopecia Universalis and Graves’ Disease in the Setting of Immune Restoration After Highly Active Antiretroviral Therapy AIDS · 2001
    61. Topical Immunotherapy in Dermatology International Journal of Clinical Practice · 1999
    62. Failure of Gluten-Free Diet in Celiac Disease-Associated Alopecia Areata Acta Dermato Venereologica · 1998
    63. Treatment of Widespread Alopecia Areata in Young Patients with Monthly Oral Corticosteroid Pulse Pediatric Dermatology · 1998
    64. Autoantibodies to Hair Follicles in C3H/HeJ Mice With Alopecia Areata-Like Hair Loss Journal of Investigative Dermatology · 1997
    65. Alopecia Areata But Not Androgenetic Alopecia Is Characterized By A Restricted And Oligoclonal T-Cell Receptor-Repertoire Among Infiltrating Lymphocytes Journal of Cutaneous Pathology · 1997
    66. Pulsed Administration of Corticosteroids in the Treatment of Alopecia Areata International Journal of Dermatology · 1996
    67. PUVA Treatment of Alopecia Areata Partialis, Totalis, and Universalis: Audit of 10 Years' Experience at St John's Institute of Dermatology British journal of dermatology/British journal of dermatology, Supplement · 1995
    68. Systemic Steroids With or Without 2% Topical Minoxidil in the Treatment of Alopecia Areata Archives of Dermatology · 1992
    69. Alopecia Areata in Children: Response to Treatment with Diphencyprone British Journal of Dermatology · 1991
    70. Treatment-Resistant Alopecia Areata: Combination Therapy with Minoxidil and Anthralin Archives of dermatology · 1990
    71. Treatment-Resistant Alopecia Areata: Response to Combination Therapy with Minoxidil Plus Anthralin Archives of Dermatology · 1990
    72. Juvenile Versus Maturity-Onset Alopecia Areata: A Comparative Retrospective Clinical Study Clinical and Experimental Dermatology · 1989
    73. Evaluation of Anthralin in the Treatment of Alopecia Areata Archives of dermatology · 1987
    74. The Spotted Lunula: Three Patients with Alopecia Areata Exhibited Spotty Absence of Whiteness in the Lunulae of Their Nails Journal of the American Academy of Dermatology · 1980
    75. Twenty-Nail Dystrophy of Alopecia Areata Archives of Dermatology · 1980

    Related research 4

    1. Resistant Alopecia Areata Treated with Tofacitinib International Journal of Trichology · 2022
    2. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    3. Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib PubMed · 2018
    4. Treating Resistant Cases of Alopecia Universalis Journal of cosmetology & trichology · 2018