Investigation of Oxidative Stress in Patients with Alopecia Areata and Its Relationship with Disease Severity, Duration, Recurrence, and Pattern

December 2014 in “ Clinical and experimental dermatology ”

Jülide Zehra Yenin, Gamze Serarslan, Zafer Yönden, Kemal Türker Ulutaş

alopecia areata oxidative stress erythrocyte superoxide dismutase glutathione peroxidase plasma malondialdehyde erythrocyte catalase AA SOD GSH-Px MDA CAT

Studysummary This study found that patients with alopecia areata had reduced erythrocyte SOD and GSH-Px activities and elevated plasma MDA levels, suggesting a potential role of oxidative stress in the disease's pathogenesis.

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The study investigated oxidative stress in 62 patients with alopecia areata (AA) compared to 62 healthy controls. It found that patients with AA had significantly reduced erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, and increased but statistically insignificant plasma malondialdehyde (MDA) levels. No significant differences were observed in erythrocyte catalase (CAT) activities or in oxidative stress markers concerning AA severity, duration, recurrence, or pattern. These results suggested a potential role of oxidative stress in the pathogenesis of AA.

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Research cited in this study

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