Treatment-Resistant Alopecia Areata: Response to Combination Therapy with Minoxidil Plus Anthralin

June 1990 in “ Archives of Dermatology ”

Virginia C. Fiedler, Andrea Wendrow, Gregory J. Szpunar, Carl M. Metzler, Richard L. DeVillez

minoxidil anthralin alopecia areata irritant dermatitis hair regrowth combination therapy systemic minoxidil absorption Rogaine

From the encyclopedia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Studysummary This study found that combination therapy with 5% minoxidil and 0.5% anthralin led to hair regrowth in some patients with severe treatment-resistant alopecia areata, but also caused mild to moderate irritant dermatitis in all participants.

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Research cited in this study

13 / 13 results

research Allergic and Irritant Contact Dermatitis Compared in the Treatment of Alopecia Totalis and Universalis: A Comparison of the Value of Topical Diphencyprone and Tretinoin Gel

36 citations , March 1989 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, the authors compared topical diphencyprone and tretinoin gel for treating alopecia totalis and universalis, but the abstract does not report any definitive clinical results.

research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

121 citations , March 1989 in “Journal of Investigative Dermatology”

Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.

research Nongenotoxicity of Minoxidil in Murine Hair Follicles as Determined by the Nuclear Aberration Assay

12 citations , January 1988 in “Toxicology and Applied Pharmacology”

Minoxidil promotes hair growth without causing DNA damage.

research Evaluation of Anthralin in the Treatment of Alopecia Areata

109 citations , November 1987 in “Archives of dermatology”

In this study, 0.5%-1.0% anthralin cream led to a cosmetic response in 25% of patients with severe alopecia areata, despite common side effects like pruritus and erythema.

research Evaluation of Oral Minoxidil in the Treatment of Alopecia Areata

34 citations , November 1987 in “Archives of Dermatology”

This study found that oral minoxidil showed limited cosmetic effectiveness in treating severe alopecia areata, with only 18% of patients experiencing a noticeable response.

research Topical Minoxidil Solution (1% and 5%) in the Treatment of Alopecia Areata

101 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil solution helps hair regrowth in alopecia areata, with 5% being more effective.

research Action of Topical Minoxidil in the Bald Stump-Tailed Macaque

78 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil promotes hair growth but stops working when discontinued.

research Immunohistochemical Characterization of the Cellular Infiltrate in Severe Alopecia Areata Before and After Minoxidil Treatment

31 citations , January 1987 in “Dermatology”

This study reports that topical minoxidil led to normalization of hair follicle characteristics in 36 of 47 severe alopecia areata patients, and indicated a shift in T cell populations, suggesting potential immunomodulatory effects.

research Topical Minoxidil in Extensive Alopecia Areata, Including 3-Year Follow-Up

34 citations , January 1987 in “Dermatology”

In this study, topical minoxidil was found to be an effective, safe, and easy treatment for individuals with alopecia areata affecting 25–99% of the scalp, but less effective for total scalp hair loss.

research Topical Minoxidil Dose-Response Effect in Alopecia Areata

54 citations , February 1986 in “Archives of Dermatology”

This study found that 5% topical minoxidil solution led to greater hair regrowth in severe alopecia areata patients compared to 1% minoxidil, although most regrowth was not cosmetically acceptable.

research Topical Minoxidil in Early Male Pattern Baldness

138 citations , August 1985 in “Journal of The American Academy of Dermatology”

Minoxidil promotes hair growth in male pattern baldness.

research Topical Minoxidil Therapy in Hereditary Androgenetic Alopecia

55 citations , February 1985 in “Archives of Dermatology”

In this randomized trial, topical minoxidil treatment resulted in cosmetically acceptable hair growth in 32% of men with hereditary male pattern baldness, with no serious side effects reported.

research Topical Treatment of Alopecia Areata

50 citations , July 1981 in “Archives of Dermatology”

This study found that applying dinitrochlorobenzene (DNCB), a contact allergen, led to hair regrowth in patients with alopecia areata, while croton oil did not have the same effect.