Alopecia Areata But Not Androgenetic Alopecia Is Characterized By A Restricted And Oligoclonal T-Cell Receptor-Repertoire Among Infiltrating Lymphocytes

    March 1997 in “ Journal of Cutaneous Pathology ”
    Daniela Dressel, Cord Henrik Brütt, Burkhard J. Manfras, Thomas Matthias Zollner, Antje Wunderlich, Bernhard O. Böhm, Wolf-Henning Boehncke
    Image of study
    TLDR Alopecia areata involves specific T-cells, unlike androgenetic alopecia.
    Alopecia areata (AA) is an autoimmune disorder characterized by a restricted and oligoclonal T-cell receptor-repertoire among infiltrating lymphocytes, while androgenetic alopecia (AGA) is not. This suggests that T cells play a significant role in AA, but not in AGA. The study involved small sample sizes of patients with AA and AGA, and further research is needed to confirm these findings. The restricted T-cell receptor repertoire in AA may lead to the development of targeted therapies for the disease.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 6 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  862 upvotes 3 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community C’est terrible - at my wits end

      in Female  444 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Fevipiprant 2019!

       17 upvotes 8 years ago
      The conversation discusses Fevipiprant, an asthma drug that may block CRTH2 and potentially stop male pattern baldness (MPB) without inhibiting DHT. It also mentions the use of finasteride and dutasteride for hair loss.

    Related Research

    1 / 1 results