Alopecia Areata But Not Androgenetic Alopecia Is Characterized By A Restricted And Oligoclonal T-Cell Receptor-Repertoire Among Infiltrating Lymphocytes

March 1997 in “ Journal of Cutaneous Pathology ”

Daniela Dressel, Cord Henrik Brütt, Burkhard J. Manfras, Thomas Matthias Zollner, Antje Wunderlich, Bernhard O. Böhm, Wolf-Henning Boehncke

alopecia areata androgenetic alopecia T-cell receptor lymphocytes autoimmune disorder targeted therapies AA AGA T cells

TLDR Alopecia areata involves specific T-cells, unlike androgenetic alopecia.

Alopecia areata (AA) is an autoimmune disorder characterized by a restricted and oligoclonal T-cell receptor-repertoire among infiltrating lymphocytes, while androgenetic alopecia (AGA) is not. This suggests that T cells play a significant role in AA, but not in AGA. The study involved small sample sizes of patients with AA and AGA, and further research is needed to confirm these findings. The restricted T-cell receptor repertoire in AA may lead to the development of targeted therapies for the disease.

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research Treatment of Chronic Severe Alopecia Areata with Topical Diphenylcyclopropenone and 5% Minoxidil: A Clinical and Immunopathologic Evaluation

41 citations, November 1993 in “Journal of The American Academy of Dermatology”

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