Increased Serum Interleukin-17A Levels Correlate with Disease Severity and Poor Prognostic Factors in Patients with Alopecia Areata

October 2021 in “ Dermatology Reports ”

Trang Le Thi Thuy, Thang Nguyen Tat, Chuyen Thi Hong Nguyen, Hao Trong Nguyen, Trung Van The

alopecia areata interleukin-17A IL-17A serum interleukin-17A atopy nail abnormalities disease severity active disease phases biomarker pathogenesis AA

Studysummary This study found that serum IL-17A levels were significantly higher in patients with alopecia areata compared to healthy controls and correlated with disease severity and activity. Our plain-language summary of this paper — not a Tressless recommendation.

In a study involving 36 patients with alopecia areata (AA) and 20 healthy controls, researchers found that serum interleukin-17A (IL-17A) levels were significantly higher in AA patients (P=0.004). Higher IL-17A levels correlated with more severe disease, personal atopy, nail abnormalities, and active disease phases. These results suggest that IL-17A is crucial in AA pathogenesis and could serve as a valuable clinical biomarker for disease severity and activity.

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Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity

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