TLDR Certain genes on chromosomes 6, 10, 16, and 18 may increase the risk of alopecia areata.
The study conducted a genomewide scan involving 20 families with 102 affected and 118 unaffected individuals to identify genetic susceptibility loci for alopecia areata (AA). It found evidence of several loci on chromosomes 6, 10, 16, and 18, with a notable maximum LOD score of 3.93 on chromosome 18. The research confirmed previous associations with the human leukocyte antigen locus and suggested that regions on chromosomes 16 and 18 might harbor genes related to skin and hair disorders. The study highlighted the complexity of AA's genetic basis and the need for further investigation to fully understand the genetic factors contributing to this autoimmune disease.
295 citations,
January 2006 in “Journal of the American Academy of Dermatology” Alopecia areata, a common autoimmune hair loss condition, often runs in families.
44 citations,
December 2005 in “Journal of Investigative Dermatology” Certain genetic markers, especially the MICA gene, are linked to alopecia areata.
185 citations,
August 2005 in “Autoimmunity Reviews” Alopecia areata is an autoimmune condition causing hair loss due to the immune system attacking hair follicles, often influenced by genetics and stress.
138 citations,
March 2001 in “Clinics in Dermatology” Hair loss can significantly affect a person's self-esteem and body image, especially in young people, those who value their looks highly, and women.
43 citations,
July 1994 in “Archives of Dermatology” People with androgenetic alopecia have more personality disorders and mental health symptoms; treatment may help.
6 citations,
January 1992 in “Advances in Dermatology” 1 citations,
January 1992 in “PubMed”
148 citations,
December 2018 in “Journal of autoimmunity” Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.
4 citations,
November 2018 in “JAAD case reports” Alopecia areata can sometimes appear as a straight line of hair loss instead of round patches.
May 2018 in “Journal of cosmetology & trichology” Combining platelet-rich plasma therapy with prostaglandin-F eye drops can significantly regrow hair in alopecia universalis.
