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GlossaryHuman Leukocyte Antigen (HLA)

group of proteins on cell surfaces aiding immune recognition

Human Leukocyte Antigen (HLA) refers to a group of proteins found on the surface of most cells in the body. These proteins play a crucial role in the immune system by helping it distinguish between the body's own cells and foreign invaders, such as viruses and bacteria. HLA typing is important in organ transplantation to ensure compatibility between donors and recipients, reducing the risk of rejection.

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Adrenal 21-Hydroxylase Gene Mutations in Slovenian Hyperandrogenic Women: Evaluation of Corticotrophin Stimulation and HLA Polymorphisms in Screening for Carrier Status

research Adrenal 21-Hydroxylase Gene Mutations in Slovenian Hyperandrogenic Women: Evaluation of Corticotrophin Stimulation and HLA Polymorphisms in Screening for Carrier Status

19 citations, August 1999 in “European journal of endocrinology”

The study concluded that testing hormone levels after stimulation is not reliable for identifying carriers of 21-hydroxylase deficiency; genetic testing is necessary.

research Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 NKG2D Lymphocytes in Alopecia Areata Patients

15 citations, December 2018 in “International journal of environmental research and public health/International journal of environmental research and public health”

EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.

research Frontal Fibrosing Alopecia and Lichen Planopilaris in HLA-Identical Mother and Daughter

12 citations, January 2015 in “Indian Journal of Dermatology, Venereology and Leprology”

A mother and daughter with similar hair loss conditions and identical HLA types suggest a genetic link between the conditions.

Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A*33:01; B*14:02; C*08:02 as a Genetic Marker

research Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A33:01; B14:02; C*08:02 as a Genetic Marker

7 citations, January 2019 in “Australasian Journal of Dermatology”

A genetic marker linked to a type of hair loss was found in most patients studied.

research Joint Study of the Associations of HLA-B and the Transmembrane Short Tandem Repeat Polymorphism of MICA Protein with Alopecia Areata Shows Independent Associations of Both with the Disease

7 citations, February 2020 in “Clinical and Experimental Dermatology”

Both HLA-B and MICA are independently linked to alopecia areata.

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