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Glossary Susceptibility Loci

specific gene locations linked to higher disease risk

Susceptibility loci are specific locations on genes that are associated with an increased risk of developing certain diseases or conditions, such as alopecia. These genetic markers can help identify individuals who are more likely to experience these health issues, providing valuable information for both diagnosis and potential treatment strategies.

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Research

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research Genomewide Scan for Linkage Reveals Evidence of Several Susceptibility Loci for Alopecia Areata

143 citations , January 2007 in “The American Journal of Human Genetics”

This study identified four genetic loci on chromosomes 6, 10, 16, and 18 that may contribute to susceptibility for alopecia areata and suggested shared genetic factors with psoriasis.

research Investigation of six novel susceptibility loci for male androgenetic alopecia in women with female pattern hair loss

25 citations , July 2013 in “Journal of Dermatological Science”

This study suggests that the androgen receptor locus on the X chromosome may play a role in the pathogenesis of early-onset female pattern hair loss.

research Investigation of four novel male androgenetic alopecia susceptibility loci: no association with female pattern hair loss

21 citations , December 2013 in “Archives of Dermatological Research”

No link found between new male baldness genes and female hair loss.

research GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk

April 2020

This genome-wide association study of over 70,000 men identified 71 genetic loci linked to male pattern baldness, highlighting pathways that could help explain its underlying biology.

research Faculty Opinions recommendation of Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

October 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Six new genes linked to early hair loss were found, which also surprisingly connect to Parkinson's disease and lower fertility.

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community Dermatologist told me to quit fin after turning 40

in Finasteride/Dutasteride 194 upvotes 2 years ago

A dermatologist advised a patient to stop taking finasteride (fin) after turning 40 due to potential risk of aggressive prostate cancer. The patient and others in the conversation debated this advice, discussing the relationship between finasteride, prostate cancer, and hair loss, and considering alternatives like topical finasteride.

community Rate my MPB Genetics: Can I run Primobolan/Masteron? (Detailed MyHeritage DNA Data Included)

in General 262 upvotes 6 months ago

The user is using testosterone and finasteride to prevent hair loss and is considering adding Primobolan or Masteron, which are DHT-derivatives. They are seeking advice on their genetic risk for male pattern baldness and whether they can safely use these compounds without significant hair loss.

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