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Glossary Genetic Variants

differences in DNA sequence among individuals

Genetic variants, also known as genetic polymorphisms, are differences in the DNA sequence among individuals. These variations can affect how genes function and can influence traits such as hair color, susceptibility to diseases like alopecia, and response to medications. While some genetic variants have no impact on health, others can be significant in understanding genetic predispositions and developing personalized medical treatments.

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Research

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research Genetic Variants Associated with Hyperandrogenemia in PCOS Pathophysiology

29 citations , February 2018 in “Genetics research international”

This review summarizes the influence of gene polymorphisms on genetic predisposition to polycystic ovary syndrome, but reports no new experimental or clinical results.

research Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay

21 citations , January 2018 in “PLoS Genetics”

This study found that certain keratin gene mutations associated with pachyonychia congenita are linked to altered enamel structure and increased risk of dental caries.

research Alopecia Areata: A Review of the Genetic Variants and Immunodeficiency Disorders Associated with Alopecia Areata

10 citations , January 2023 in “Skin Appendage Disorders”

This review discusses the histological features and diagnostic challenges of alopecia areata and emphasizes the need for genetic research to develop future therapeutics; it reports no new clinical findings.

research Genetic Variants at 20p11 Confer Risk to Androgenetic Alopecia in the Chinese Han Population

9 citations , August 2013 in “PLOS ONE”

This study validated that the 20p11 genetic locus is associated with increased risk of androgenic alopecia in the Chinese Han population, suggesting shared genetic factors between Chinese and European populations.

Minoxidil Sulfotransferase Enzyme (SULT1A1) Genetic Variants Predict Response to Oral Minoxidil Treatment for Female Pattern Hair Loss

research Minoxidil Sulfotransferase Enzyme (SULT1A1) genetic variants predicts response to oral minoxidil treatment for female pattern hair loss

7 citations , June 2020 in “Journal of The European Academy of Dermatology and Venereology”

This article discusses the role of Minoxidil Sulfotransferase Enzyme (SULT1A1) genetic variants in predicting the response to oral minoxidil for treating female pattern hair loss, without presenting new research findings.

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Community Join

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community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

112 upvotes 1 year ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

community A man in his 80s with full head of hair.

473 upvotes 4 months ago

Genetics play a major role in hair loss, with some people keeping a full head of hair into old age without using treatments like minoxidil or finasteride. Many express frustration over their own hair loss and the perceived unfairness of genetic differences.

community Oral Minoxidil - The Hyper-Responder Concept

4 upvotes 10 months ago

Minoxidil's effectiveness varies due to genetic differences in the SULT1A1 enzyme, affecting how well it converts to its active form, minoxidil sulfate. Hyper-responders may experience rapid hair growth and increased side effects, such as pericardial effusion, even at low doses.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community What is preventing GT20029 from being the cure to androgenetic hair loss?

10 upvotes 1 year ago

GT20029 is discussed as a potential treatment for androgenetic hair loss by targeting androgen receptors, unlike finasteride which reduces DHT broadly. Concerns include its effectiveness, genetic variations in androgen receptors, and availability, with some skepticism about its potential as a true alternative.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Vitamin B1

Thinning hair over time? It might not just be genetics: lack of B1 and B2 could be silently working against you. There is no verified human trial showing that B1 or B2 deficiency causes thinning hair or that correcting it regrows hair; a 2019 review concludes the role of micronutrients in hair loss is real but unclear and still needs controlled trials.

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