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Glossary Genetic Loci for Patterned Hair Loss Susceptibility

specific gene locations linked to increased risk of hair loss

Genetic loci for patterned hair loss susceptibility refer to specific locations on genes that are associated with an increased risk of developing patterned hair loss, such as male or female pattern baldness. These loci contain variations in DNA that can influence how likely a person is to experience hair thinning or loss, often inherited from their parents. Understanding these genetic markers helps researchers and medical professionals identify individuals at higher risk and develop targeted treatments.

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Research

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research Investigation of the male pattern baldness major genetic susceptibility loci AR/EDA2R and 20p11 in female pattern hair loss

38 citations , February 2012 in “British Journal of Dermatology”

This study suggests that the AR/EDA2R locus may contribute to early-onset female pattern hair loss, but no association was found with the 20p11 locus.

research Evaluation of Susceptibility Genes/Loci Associated with Male Androgenetic Alopecia (MAGA) for Female-Pattern Hair Loss in a Chinese Han Population and a Brief Literature Review

1 citations , August 2021 in “Medical Science Monitor”

This study found no significant association between genetic loci linked to male androgenetic alopecia and female-pattern hair loss in a Chinese Han population, suggesting they are etiologically separate disorders.

Genetics and Other Factors in the Etiology of Female Pattern Hair Loss

research Genetics and other factors in the aetiology of female pattern hair loss

43 citations , April 2017 in “Experimental Dermatology”

This review summarizes the genetic studies on female pattern hair loss, highlighting the lack of clearly identified susceptibility loci and suggesting distinct aetiological differences from male pattern hair loss.

research Investigation of four novel male androgenetic alopecia susceptibility loci: no association with female pattern hair loss

21 citations , December 2013 in “Archives of Dermatological Research”

No link found between new male baldness genes and female hair loss.

research Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

87 citations , May 2012 in “PLOS Genetics”

This study found that early-onset androgenetic alopecia in individuals of European ancestry is significantly associated with increased odds of Parkinson's disease and is influenced by specific genetic loci, including some linked to reduced fertility.

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community Genomic Sequencing for Hair Loss

in Research/Science 156 upvotes 5 months ago

Hair loss treatments like Minoxidil, finasteride, and potential mRNA therapies are discussed. There is skepticism about targeting specific genes due to the complex genetic nature of hair loss.

community I don’t think my hair loss is caused by DHT – quitting finasteride after 3 months (1 mg). Need opinions

6 months ago

The user plans to stop finasteride after three months, believing hair loss isn't due to DHT, and will continue with oral minoxidil, microneedling, and ketoconazole shampoo. They suspect stress and poor nutrition are the main causes and seek opinions on DHT blockers' effectiveness.

community Hair loss research is a money grab

227 upvotes 10 months ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

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Learn

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learn Hair Transplant

What is male pattern baldness? Male pattern baldness is a genetic condition causing hair loss in men, starting with a receding hairline.
What causes male pattern baldness? Male pattern baldness is caused by genetic sensitivity to the hormone DHT.

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn TDM-105795

What types of alopecia or hair loss conditions might TDM-105795 be designed to target based on current research? TDM-105795 may target non-scarring alopecia, particularly androgenetic alopecia.

learn KY19382

compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn GHK-Cu

Heard alopecia areata leaves scar-like spots? Some peptides are helping those areas regrow hair. Alopecia areata patches usually still have living follicles. Peptides are being studied as a possible add-on, but the evidence is small and early. See a dermatologist for treatment.

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