31 citations,
January 2010 in “GenomeBiology.com (London. Print)” The research concluded that selection significantly shaped the genetic variation of the X chromosome, with certain regions affected by past selective events.
26 citations,
February 1998 in “Chemico-Biological Interactions” Scientists identified three genes important for processing certain brain chemicals, thyroid hormones, and medications.
143 citations,
January 2007 in “The American Journal of Human Genetics” The study conducted a genomewide search for genetic linkage in 20 families with alopecia areata (AA), involving 102 affected and 118 unaffected individuals from the U.S. and Israel. It identified at least four susceptibility loci on chromosomes 6, 10, 16, and 18, with significant LOD scores on chromosomes 16 and 18. The findings supported previous associations of the human leukocyte antigen locus with AA and suggested that regions on chromosomes 16 and 18 might harbor genes involved in various skin and hair disorders. The study highlighted the complex genetic nature of AA, an autoimmune disorder affecting 1%-2% of the U.S. population, characterized by hair loss and psychological impact.
44 citations,
November 2009 in “Archives of Dermatology” CYLD mutations cause a variety of skin tumors with symptoms starting around age 16, and treatments are currently limited.
February 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” Tandem repeats significantly influence hair color, especially darker shades, across different ancestries.