Mapping of a Novel Locus for Keratosis Follicularis Squamosa on Chromosome 7p14.3–7p12.1

    September 2010 in “ Journal of Dermatological Science ”
    Yuemei Ma, Yanhua Liang, Songbin Fu, Yunqing Ren, Linlin Ma, Yin Xian, Liangdan Sun, Yong Cui, Y.F. Liu, J. Zhang, Wei Huang, Min Gao, Y.Z. Li
    Image of study
    TLDR A new gene location for Keratosis follicularis squamosa was found on chromosome 7p14.3-7p12.1.
    In a study involving a five-generation Chinese family with 69 individuals, where 23 were affected by Keratosis follicularis squamosa (KFS), researchers identified a new genetic locus for KFS on chromosome 7p14.3-7p12.1. The study focused on 23 family members, including 11 KFS patients and 12 healthy individuals, and utilized genome-wide linkage analysis with microsatellite markers. The most significant linkage was found with a LOD score of 4.51 at marker D7S691, and the KFS gene was localized to a 19.28 cM interval between markers D7S484 and D7S2422, which contains about 159 genes. Additionally, the authors discussed the creation of immortalized human dermal papilla cells (DPCs) by transfecting them with SV40T antigen and c-myc gene, which maintained their hair growth-promoting properties, potentially aiding future hair biology research and treatment development for hair loss conditions.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 15 results

      community My skin is always dry and flakes like chalk (25)

      in Transgender  6 upvotes 8 months ago
      The user underwent a biopsy two years ago and was diagnosed with keratosis pilaris, leading to hair issues. They tried treatments including Minoxidil, betamethasone, lymecycline, topical Accutane, and dutasteride, as well as diet changes, without improvement in hair thickness or skin dryness.

      community What are these spots on my scalp

      in Treatment  51 upvotes 5 months ago
      A user noticed non-itchy, non-bleeding spots on their scalp while experiencing hair loss. Replies suggest the spots are likely sunspots or liver spots and recommend seeing a dermatologist; hair loss is attributed to male pattern baldness.

      community My Experience and a Discourse on "DUPA"

      in Treatment  9 upvotes 6 months ago
      The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

      community The hardest hair protocol ever!

      in Research/Science  10 upvotes 2 years ago
      The user is using RU58841, finasteride, dutasteride, and minoxidil to slow down aggressive hair loss but is still experiencing hair shedding due to high testosterone levels. They plan to use ostarine to lower testosterone and prevent hair loss while maintaining muscle mass, and will continue using the other treatments.

    Similar Research

    5 / 1000+ results