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GlossaryCOL17A1

gene encoding a protein crucial for skin and hair integrity

COL17A1 is a gene that encodes for a protein called collagen type XVII, alpha 1. This protein is crucial for the structural integrity of the skin, as it helps anchor the outer layer of the skin (epidermis) to the underlying layer (dermis). Mutations in the COL17A1 gene can lead to skin disorders and hair loss conditions, such as epidermolysis bullosa and certain types of alopecia.

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research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis

242 citations, February 2016 in “Science”

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

Expression of Anti-Aging Type-XVII Collagen (COL17A1/BP180) in Hair Follicle-Associated Pluripotent (HAP) Stem Cells During Differentiation

research Expression of Anti-Aging Type-XVII Collagen (COL17A1/BP180) in Hair Follicle-Associated Pluripotent (HAP) Stem Cells During Differentiation

11 citations, June 2019 in “Tissue & Cell”

Hair stem cells produce a protein called COL17A1 that plays a key role in their development and is linked to hair thinning and baldness.

research Signature Selection Analysis Reveals Candidate Genes Associated With Production Traits in Iranian Sheep Breeds

55 citations, December 2021 in “BMC Veterinary Research”

Certain genes in Iranian sheep are linked to wool production and heat adaptation.

research Read-Through for Nonsense Mutations in Type XVII Collagen-Deficient Junctional Epidermolysis Bullosa

5 citations, April 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

A new therapy for a skin blistering condition has not been developed yet.

research Keratinocyte Stem Cells: Role in Aging

1 citations, March 2022 in “IntechOpen eBooks”

Aging reduces skin stem cell function, leading to changes like hair loss and slower wound healing.

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community Physio-metabolic method (antiandrogen, minoxidil, leg training and cold)

in Treatments 309 upvotes 5 months ago

The method combines finasteride, minoxidil, intense leg exercises, and cold exposure to treat androgenetic alopecia. It aims to boost metabolism and reduce androgenic effects, enhancing hair growth.

community How does dutasteride regrowth work?

in Finasteride/Dutasteride 6 upvotes 6 months ago

A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

community Stop expecting results in 2 months!

in Treatment 125 upvotes 6 months ago

People discussing hair loss treatments emphasize the need for patience, as results from using finasteride and minoxidil can take 8-12 months or longer. Some users report early signs of improvement, while others experience continued shedding or slower progress.

community What should I expect from dutasteride?

in Finasteride/Dutasteride 2 upvotes 3 years ago

The user tried Minoxidil, PRP, Hair Carboxytherapy, and topical Dutasteride with limited success and is now on oral Dutasteride. They are experiencing some hair loss reduction but no significant density improvement, leading to feelings of depression.