Restoration of Hair Luster via Novel Biomarker COL7A1 by Minoxidil, Caffeine, and Biotin

The study examines the restoration of hair luster by targeting the biomarker COL7A1 using minoxidil, caffeine, and biotin. Researchers used UVB-induced mouse models and human hair follicle tissues to demonstrate that UVB exposure suppresses luster-related genes, including COL7A1. Treatments with these compounds restored the expression of COL7A1 and other genes associated with hair cuticle integrity, suggesting their potential in enhancing hair luster. The study involved 5 human donors for ex vivo experiments and small sample sizes for gene expression analysis, highlighting the need for further clinical trials to validate these findings. The research provides a molecular framework for future interventions aimed at improving hair luster and follicular health.