Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer

The document discussed the role of Transglutaminase 3 (TGM3) in epithelial differentiation and its involvement in various cancers. TGM3 was crucial for the formation and maintenance of the epithelial barrier, influencing cell adhesion and migration. Dysregulation of TGM3 contributed to cancer development and progression by affecting apoptosis and proliferation. TGM3 was also significant in hair follicle development, particularly in keratinization and cross-linking processes essential for hair shaft growth. Mutations in TGM3 were linked to hair and skin abnormalities, such as uncombable hair syndrome and dermatitis herpetiformis. TGM3's expression levels varied in different cancers, suggesting its potential as a cancer biomarker and therapeutic target. Further research was needed to understand TGM3's dual role in cancer and other pathologies.