Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer

    August 2020 in “ Cells ”
    E. S. Chermnykh, Е. В. Алпеева, E. A. Vorotelyak
    Studysummary This review discusses the role of TGM3 in skin and hair follicle biology, human tumor pathology, and genetic abnormalities, and reports no novel results; the authors highlight its potential as a cancer diagnostic biomarker.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 24

    1. A Girl With Loose Anagen Hair Syndrome And Concurrent Uncombable Hair Syndrome JAAD Case Reports · 2020
    2. Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases International Journal of Molecular Sciences · 2020
    3. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016
    4. Hair Follicle Morphogenesis and Epidermal Homeostasis in We/We Wal/Wal Mice with Postnatal Alopecia Histochemistry and Cell Biology · 2014
    5. The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2009
    6. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    7. Cortical Cell Types and Intermediate Filament Arrangements Correlate with Fiber Curvature in Japanese Human Hair Journal of structural biology · 2008
    8. Transglutaminase-3 Enzyme: A Putative Actor in Human Hair Shaft Scaffolding? ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    9. Scratching the Surface of Skin Development Nature · 2007
    10. Cystatin M/E Is a High Affinity Inhibitor of Cathepsin V and Cathepsin L by a Reactive Site Distinct from the Legumain-binding Site Journal of biological chemistry/˜The œJournal of biological chemistry · 2006
    11. Transglutaminase 5 Expression in Human Hair Follicle Journal of Investigative Dermatology · 2005
    12. Trichohyalin Mechanically Strengthens the Hair Follicle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003
    13. Epithelial Barrier Function: Assembly and Structural Features of the Cornified Cell Envelope BioEssays · 2002
    14. Targeted Inactivation of Gh/Tissue Transglutaminase II Journal of Biological Chemistry · 2001
    15. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    16. In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments ˜The œjournal of cell biology/˜The œJournal of cell biology · 2000
    17. Human Peptidylarginine Deiminase Type III: Molecular Cloning and Nucleotide Sequence of the cDNA, Properties of the Recombinant Enzyme, and Immunohistochemical Localization in Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2000
    18. Transglutaminase-3, an Esophageal Cancer-Related Gene International Journal of Cancer · 2000
    19. The Fate of Trichohyalin Journal of biological chemistry/˜The œJournal of biological chemistry · 1997
    20. Immunohistochemical Analysis of Tissue Remodeling During the Anagen-Catagen Transition of the Human Hair Follicle British Journal of Dermatology · 1997
    21. The Deduced Sequence of the Novel Protransglutaminase E (TGase3) of Human and Mouse Journal of Biological Chemistry · 1993
    22. Uncombable Hair (Pili Trianguli Et Canaliculi): Evidence for Dominant Inheritance with Complete Penetrance Based on Scanning Electron Microscopy American Journal of Medical Genetics · 1987
    23. Uncombable Hair Syndrome: Observations on Response to Biotin and Occurrence in Siblings with Ectodermal Dysplasia Journal of the American Academy of Dermatology · 1985
    24. Human Epidermal Transglutaminase: Preparation and Properties Journal of Biological Chemistry · 1976