Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer

August 2020 in “ Cells ”

E. S. Chermnykh, Е. В. Алпеева, E. A. Vorotelyak

transglutaminase 3 TGM3 epidermis hair follicles keratinocytes cornified cells hair follicle shaft hair follicle abnormalities TGM3 mutations

TLDR TGM3 is important for skin and hair structure and may help diagnose cancer.

Transglutaminase 3 (TGM3) played a crucial role in the formation of protein polymers in the epidermis and hair follicles, contributing to their protective and barrier functions. It was essential for the structural transformation of keratinocytes into cornified cells in the epidermis and the hardening of the hair follicle and shaft. Despite its known involvement in skin and hair follicle physiology and pathology, the full extent of TGM3's roles, substrates, and importance remained unclear. Recent advances highlighted TGM3's significance in human tumor pathology and its potential as a cancer diagnosis biomarker. Additionally, the review addressed hair follicle abnormalities in humans and mice linked to TGM3 mutations.

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