Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer

August 2020 in “ Cells ”

E. S. Chermnykh, Е. В. Алпеева, E. A. Vorotelyak

transglutaminase 3 TGM3 epidermis hair follicles keratinocytes cornified cells hair follicle shaft hair follicle abnormalities TGM3 mutations

Studysummary This review discusses the role of TGM3 in skin and hair follicle biology, human tumor pathology, and genetic abnormalities, and reports no novel results; the authors highlight its potential as a cancer diagnostic biomarker.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document discussed the role of Transglutaminase 3 (TGM3) in epithelial differentiation and its involvement in various cancers. TGM3 was crucial for the formation and maintenance of the epithelial barrier, influencing cell adhesion and migration. Dysregulation of TGM3 contributed to cancer development and progression by affecting apoptosis and proliferation. TGM3 was also significant in hair follicle development, particularly in keratinization and cross-linking processes essential for hair shaft growth. Mutations in TGM3 were linked to hair and skin abnormalities, such as uncombable hair syndrome and dermatitis herpetiformis. TGM3's expression levels varied in different cancers, suggesting its potential as a cancer biomarker and therapeutic target. Further research was needed to understand TGM3's dual role in cancer and other pathologies.

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