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GlossaryTransglutaminase 3 (TGM3)

enzyme crucial for skin and hair protein cross-linking

Transglutaminase 3 (TGM3) is an enzyme that plays a crucial role in the formation and maintenance of the outer layer of the skin and hair follicles. It helps in the cross-linking of proteins, which strengthens the structural integrity of these tissues. Deficiencies or malfunctions in TGM3 can lead to skin disorders and hair loss conditions.

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research Qu-Shi-Yu-Fa Decoction Promotes Hair Cycle and Keratinization by Upregulating Foxn1 and Tgm3 to Treat Androgenetic Alopecia

January 2024

research The Proximal Promoter of the Human Transglutaminase 3 Gene

105 citations, February 1996 in “Journal of biological chemistry/The Journal of biological chemistry”

The TGM3 gene's promoter region is key for skin and hair cell function and may aid gene therapy.

research Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer

22 citations, August 2020 in “Cells”

TGM3 is important for skin and hair structure and may help diagnose cancer.

research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

119 citations, November 2016 in “American journal of human genetics”

Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.

research Uncombable Hair Syndrome and Beyond

January 2022 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)”

Uncombable hair syndrome causes frizzy hair and can affect the nervous system, eyes, and ears, often co-occurring with other hair, skin, nail, and teeth conditions, and is linked to three specific gene mutations.

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