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GlossaryTransglutaminase 3

enzyme crucial for skin and hair protein cross-linking

Transglutaminase 3 (TGM3) is an enzyme that plays a crucial role in the formation and maintenance of the outer layer of the skin and hair follicles. It helps in the cross-linking of proteins, which strengthens the structural integrity of these tissues. Deficiencies or malfunctions in TGM3 can lead to skin disorders and hair loss conditions.

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research The Proximal Promoter of the Human Transglutaminase 3 Gene

105 citations, February 1996 in “Journal of biological chemistry/The Journal of biological chemistry”

The TGM3 gene's promoter region is key for skin and hair cell function and may aid gene therapy.

research Identification of a Preferred Substrate Peptide for Transglutaminase 3 and Detection of In Situ Activity in Skin and Hair Follicles

35 citations, July 2010 in “The FEBS journal”

The study found a specific peptide that helps detect TGase 3 activity in skin and hair follicles.

research Transglutaminase-3 Enzyme: A Putative Actor in Human Hair Shaft Scaffolding?

30 citations, August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

TGase 3 helps build hair structure by forming strong bonds between proteins.

research Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer

22 citations, August 2020 in “Cells”

TGM3 is important for skin and hair structure and may help diagnose cancer.

research Involvement of Transglutaminase 3 in Hair Stiffness Changes with Age by Zinc Capture

March 2024 in “Nihon Keshouhin Gijutsushakaishi/Journal of S C C./Nihon Keshouhin Gijutsushakai kaishi”

Hair becomes less stiff as we age because of a decrease in zinc, which is linked to lower levels of the protein TG3.

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