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GlossaryTransglutaminase

enzyme that cross-links proteins, crucial for hair strength

Transglutaminase, often abbreviated as TGase, is an enzyme that catalyzes the formation of covalent bonds between proteins, specifically by linking the amino acid glutamine to lysine. This process is crucial for various biological functions, including blood clotting, skin formation, and hair follicle development. In the context of hair, transglutaminase helps strengthen the hair shaft by cross-linking keratin proteins, contributing to hair's structural integrity and resilience.

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research The Proximal Promoter of the Human Transglutaminase 3 Gene

105 citations , February 1996 in “Journal of biological chemistry/The Journal of biological chemistry”

The TGM3 gene's promoter region is key for skin and hair cell function and may aid gene therapy.

research Transglutaminase from Hair Follicle of Guinea Pig

103 citations , February 1972 in “Proceedings of the National Academy of Sciences”

A unique enzyme in guinea pig hair follicles helps form protein cross-links in hair.

research Kinetic Studies With Transglutaminases

91 citations , May 1972 in “Journal of Biological Chemistry”

Transglutaminases work through a ping-pong mechanism, and human plasma and platelet transglutaminases have similar catalytic subunits.

research Identification of a Preferred Substrate Peptide for Transglutaminase 3 and Detection of In Situ Activity in Skin and Hair Follicles

35 citations , July 2010 in “The FEBS journal”

The study found a specific peptide that helps detect TGase 3 activity in skin and hair follicles.

research Transglutaminase-3, an Esophageal Cancer-Related Gene

32 citations , January 2000 in “International Journal of Cancer”

Transglutaminase-3 is often reduced in esophageal cancer.

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