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    Glossary Transglutaminase

    enzyme that cross-links proteins, crucial for hair strength

    Transglutaminase, often abbreviated as TGase, is an enzyme that catalyzes the formation of covalent bonds between proteins, specifically by linking the amino acid glutamine to lysine. This process is crucial for various biological functions, including blood clotting, skin formation, and hair follicle development. In the context of hair, transglutaminase helps strengthen the hair shaft by cross-linking keratin proteins, contributing to hair's structural integrity and resilience.

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    1. Human epidermal transglutaminase. Preparation and properties. Journal of Biological Chemistry · 1976 · 138 citations
    2. The Proximal Promoter of the Human Transglutaminase 3 Gene 1996 · 105 citations
    3. Transglutaminase from Hair Follicle of Guinea Pig Proceedings of the National Academy of Sciences · 1972 · 103 citations
    4. Kinetic Studies with Transglutaminases Journal of Biological Chemistry · 1972 · 91 citations
    5. Identification of a preferred substrate peptide for transglutaminase 3 and detection of <i>in situ</i> activity in skin and hair follicles ˜The œFEBS journal · 2010 · 35 citations
    6. Transglutaminase-3, an esophageal cancer-related gene International Journal of Cancer · 2000 · 32 citations
    7. Transglutaminase-3 Enzyme: A Putative Actor in Human Hair Shaft Scaffolding? 2008 · 30 citations
    8. Transglutaminase 5 Expression in Human Hair Follicle Journal of Investigative Dermatology · 2005 · 28 citations
    9. Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer Cells · 2020 · 22 citations
    10. Lamellar ichthyosis with pseudoexon activation in the transglutaminase 1 gene Journal of dermatology · 2015 · 10 citations
    11. Transglutaminase Activity Is Conserved in Stratified Epithelia and Skin Appendages of Mammals and Birds International journal of molecular sciences · 2023 · 8 citations
    12. Purification and Calcium Dependence of Transglutaminases from Sheep Hair Follicles Bioscience Biotechnology and Biochemistry · 1997 · 7 citations
    13. Repair of damaged hair protein fiber by jointly using transglutaminase and keratin ScienceAsia · 2021 · 3 citations
    14. Application of Transglutaminase for Hair Revitalization Journal of the Society of Cosmetic Scientists of Korea · 2013 · 3 citations
    15. Transglutaminase-mediated cross-linking in mammalian epidermis 1984 · 3 citations
    16. An investigation into the action of transglutaminase on human hair Journal of the Society of Cosmetic Chemists · 1995
    17. 130 Dermal IgA deposition targeted against Transglutaminase 3 in Dermatitis herpetiformis risk groups Journal of Investigative Dermatology · 2024
    18. Involvement of Transglutaminase 3 (TG3) in Hair Stiffness Changing with Age by Capture of Zinc 2024
    19. 1329 Transglutaminase 2 deficiency leads to lipid accumulation and reduced autophagy in SZ95 sebocytes 2023
    20. 110 Transglutaminase 2 is a potential regulator of sebocyte maturation 2017
    21. Hair Follicle Transglutaminases and the Formation of ε-(γ-Glutamyl) Cross-links 1981
    22. Trans glutaminase-mediated cross-linking in mammalian epidermis Molecular and Cellular Biochemistry · 1984 · 44 citations
    23. Human Epidermal Transglutaminase Journal of Investigative Dermatology · 1983 · 53 citations
    24. Biochemistry of Transglutaminases and Cross-Linking in the Skin Journal of Investigative Dermatology · 1983 · 57 citations
    25. Epidermal and hair follicle transglutaminases and crosslinking in skin 1984 · 1 citations
    26. Targeted Inactivation of Gh/Tissue Transglutaminase II Journal of Biological Chemistry · 2001 · 288 citations
    27. [Studies on enzyme activities in the hair root in male pattern baldness: glycolytic enzyme, acid hydrolase, transglutaminase and ornithine decarboxylase activities of plucked hair roots]. PubMed · 1985
    28. Epithelial barrier function: assembly and structural features of the cornified cell envelope BioEssays · 2002 · 425 citations
    29. Apoptosis in human skin development: Morphogenesis, periderm, and stem cells Developmental dynamics · 1994 · 253 citations
    30. The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein Journal of Biological Chemistry · 1993 · 161 citations