Deimination In Epidermal Barrier And Hair Formation

    October 2023 in “ Philosophical transactions - Royal Society. Biological sciences ”
    Marie-Claire Méchin, Michel Simon
    Studysummary This article reports that mutations in the PADI3 gene, affecting its activity or localization, cause uncombable hair syndrome and are linked to central centrifugal cicatricial alopecia, particularly among women of African ancestry.
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    Research cited in this study 13

    1. Uncombable Hair Syndrome and Beyond Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.) · 2022
    2. Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases International Journal of Molecular Sciences · 2020
    3. Variant PADI3 in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019
    4. Central Centrifugal Cicatricial Alopecia: New Insights and a Call for Action Journal of Investigative Dermatology Symposium Proceedings · 2017
    5. Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles Biological & pharmaceutical bulletin · 2017
    6. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016
    7. A Genome-Wide Association Scan in Admixed Latin Americans Identifies Loci Influencing Facial and Scalp Hair Features Nature Communications · 2016
    8. Evaluation of the Predictive Capacity of DNA Variants Associated with Straight Hair in Europeans Forensic Science International: Genetics · 2015
    9. Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans American journal of human genetics · 2009
    10. Peptidylarginine Deiminase Isoforms Are Differentially Expressed in Anagen Hair Follicles and Other Human Skin Appendages Journal of Investigative Dermatology · 2005
    11. Trichohyalin Mechanically Strengthens the Hair Follicle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003
    12. The Fate of Trichohyalin Journal of biological chemistry/˜The œJournal of biological chemistry · 1997
    13. Trichohyalin: A Structural Protein of Hair, Tongue, Nail, and Epidermis ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993