TLDR A potential treatment for atopic dermatitis could be to increase PADI1 expression to improve skin barrier function.
The study "Citrullination at the Inflammatory Skin Barrier" investigates the role of PADI1 in atopic dermatitis (AD). It reveals that PADI1 expression is reduced in AD-affected skin, leading to decreased citrullination of proteins crucial for skin barrier function. Baricitinib, a JAK1/2 inhibitor, can counteract this reduction, suggesting a therapeutic potential. The research indicates that restoring PADI1 expression might improve skin barrier function in AD, though the impact on enzyme activity is still uncertain. Future studies may look into drug combinations to boost PADI1 expression and activity, offering new treatment possibilities for inflammatory skin conditions.
5 citations,
December 2021 in “Frontiers in Cell and Developmental Biology” Enzymes called PADIs play a key role in hair growth and loss.
4 citations,
January 2017 in “Biological & pharmaceutical bulletin” Inhibiting ALOX12 can help hair cuticle maturation by increasing S100A3 citrullination.
5 citations,
December 2021 in “Frontiers in Cell and Developmental Biology” Enzymes called PADIs play a key role in hair growth and loss.
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October 2022 in “Frontiers in Cell and Developmental Biology” Aging skin is affected by inflammation, reduced stem cell function, and slower wound healing.
2 citations,
October 2023 in “Philosophical transactions - Royal Society. Biological sciences” Enzymes that change arginine to citrulline are important for skin barrier and hair formation, and their malfunction can lead to skin conditions and hair disorders.
