Specific Citrullination Causes Assembly of a Globular S100A3 Homotetramer

December 2007 in “ Journal of biological chemistry/The Journal of biological chemistry ”

Kenji Kizawa, Hidenari Takahara, Heinz Troxler, P. Kleinert, Urara Mochida, Claus W. Heizmann

citrullination S100A3 homotetramer Ca2+-binding peptidylarginine deiminases PAD3 arginine residues hair cuticular barrier epithelial Ca2+-cycling systems calcium-binding PAD enzymes hair barrier

Studysummary This study found that enzymatic conversion of Arg-51 in S100A3 protein to citrulline promotes homotetramer assembly, potentially increasing Ca²⁺ binding required for hair cuticular barrier formation.

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