In Silico Analysis of Gene Expression Data from Bald Frontal and Haired Occipital Scalp to Identify Candidate Genes in Male Androgenetic Alopecia

September 2019 in “ Archives of Dermatological Research ”

A. Premanand, B. Reena Rajkumari

androgenetic alopecia gene expression differentially expressed genes Wnt signaling TGF-beta signaling oxidative stress pathways AGA DEGs

TLDR Found 32 genes linked to male baldness, affecting hair growth and stress-related pathways.

This study aimed to identify candidate genes involved in male androgenetic alopecia (AGA) through an in silico search strategy. The researchers analyzed gene expression data from bald frontal and haired occipital scalp and identified 32 differentially expressed genes (DEGs) common to all five subjects. The down-regulated DEGs participate in Wnt signaling, TGF-beta signaling, and up-regulated DEGs participate in oxidative-stress-related pathways. The study suggests that further studies on protein expression levels of these genes and gene knockout studies may help identify druggable targets for AGA.

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In Silico Analysis of Gene Expression Data from Bald Frontal and Haired Occipital Scalp to Identify Candidate Genes in Male Androgenetic Alopecia

research In Silico Analysis of Gene Expression Data from Bald Frontal and Haired Occipital Scalp to Identify Candidate Genes in Male Androgenetic Alopecia

6 citations, September 2019 in “Archives of Dermatological Research”

Found 32 genes linked to male baldness, affecting hair growth and stress-related pathways.