August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review suggests that hair loss involves a complex interplay of androgen signaling with various regenerative and inflammatory pathways, challenging the view of dihydrotestosterone as the sole cause.
April 2026 in “Journal of Cosmetic Dermatology” This study found that exosomes derived from human umbilical cord mesenchymal stem cells helped preserve melanocyte function and mitigate stress-induced hair depigmentation in mice by activating the Nrf2-ARE antioxidant pathway under acute neurogenic oxidative stress.
December 2025 in “Biomedicine & Pharmacotherapy” This study found that Melamax®, originally developed as an eco-friendly hair dye, provides significant protection against ultraviolet-induced oxidative and inflammatory damage in keratinocytes by modulating gene expression and signaling pathways, highlighting its dual potential for cosmetic coloration and skin photoprotection.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that particulate matter can induce inflammation in human outer root sheath cells, potentially affecting hair growth, through oxidative stress-dependent MAPK and JAK-STAT signaling pathways.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This narrative literature review by LUSTRAO examines the complex biological mechanisms influencing hair growth and loss, highlighting that androgen signalling, while significant, works within a network involving regenerative, inflammatory, and vascular processes, without establishing it as the sole explanation for conditions like androgenetic alopecia.