TLDR AGA linked to inflammation, stress, fibrosis, and disturbed hair follicle stem cells.
This study investigated gene expression in hair follicles of individuals with androgenetic alopecia (AGA) compared to those without. The researchers found that genes regulating inflammation, stress, and fibrosis were over-expressed in all AGA groups compared to control groups, with micro-inflammation being responsible for AGA. The study identified some differentially-expressed genes in the bugle area and linked their function with hair follicle stem cells pathology in the complex etiology of AGA. The study provides novel insights into AGA pathogenesis, including the pathologic framework of "inflammation-stress-fibrosis" and disturbed hair follicle stem cells maintenance.
117 citations,
March 2017 in “Nature Communications” Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.
242 citations,
February 2016 in “Science” Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
4 citations,
May 2014 in “European Journal of Dermatology” Severe hair loss links to metabolic issues in older men with psoriasis.
13 citations,
January 2013 in “International Journal of Trichology” Inflammation around hair follicles may worsen hair loss; evaluating and treating it can improve transplant results.
54 citations,
December 2011 in “American Journal Of Pathology” A Gsdma3 mutation causes hair loss due to stem cell damage from skin inflammation.
235 citations,
January 2011 in “Journal of Clinical Investigation” Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.
131 citations,
August 2000 in “International Journal of Dermatology” Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.
8 citations,
November 2017 in “Journal of Investigative Dermatology” AGA linked to inflammation, stress, fibrosis, and disturbed hair follicle stem cells.
