Image

    Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis

    February 2016 in “ Science ”
    Hiroyuki Matsumura, Yasuaki Mohri, Nguyen Thanh Binh … Emi K. Nishimura
    Studysummary This research found that Foxc1 transcription factor and COL17A1 are critical in regulating quiescence and hair thinning in hair follicle stem cells, with aging-related DNA damage leading to hair loss.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on science.org →
    Discuss this study in the Community →

    Research cited in this study 17

    1. Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice Nature · 2015
    2. Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4 Journal of Investigative Dermatology · 2014
    3. Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology Journal of Investigative Dermatology · 2013
    4. Age-Associated Inflammation Inhibits Epidermal Stem Cell Function Genes & development · 2012
    5. The Circadian Molecular Clock Creates Epidermal Stem Cell Heterogeneity Nature · 2011
    6. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    7. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    8. Epidermal Stem Cell Diversity and Quiescence EMBO molecular medicine · 2009
    9. Epidermal Notch Signaling: Differentiation, Cancer, and Adhesion Current opinion in cell biology · 2008
    10. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    11. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    12. Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells Genes & development · 2005
    13. Shared Phenotypes Among Segmental Progeroid Syndromes Suggest Underlying Pathways of Aging The Journals of Gerontology Series A · 2005
    14. Permanent Alopecia After Cranial Irradiation: Dose–Response Relationship International journal of radiation oncology, biology, physics · 2004
    15. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    16. A Mouse Model for the Basal Transcription and DNA Repair Syndrome Trichothiodystrophy Molecular cell · 1998
    17. The Comparative Histopathology of Male-Pattern Baldness and Senescent Baldness Clinics in Dermatology · 1988

    Related research 6

    1. Aging of Hair Follicle Stem Cells and Their Niches Journal of Biochemistry and Molecular Biology · 2022
    2. Aging in Hair Follicle Stem Cells and Niche Microenvironment The Journal of Dermatology · 2017
    3. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    4. Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015
    5. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    6. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001