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Glossary Hair Follicle Aging

gradual decline in hair follicle function and structure over time

Hair Follicle Aging refers to the gradual decline in the function and structure of hair follicles over time. This process can lead to thinner, weaker hair, slower growth rates, and eventually hair loss. Factors contributing to hair follicle aging include genetic predisposition, hormonal changes, oxidative stress, and reduced cellular regeneration.

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Research

5 / 1000+ results

research Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

242 citations , February 2016 in “Science”

This research found that Foxc1 transcription factor and COL17A1 are critical in regulating quiescence and hair thinning in hair follicle stem cells, with aging-related DNA damage leading to hair loss.

research Histopathology of aging of the hair follicle

31 citations , April 2019 in “Journal of Cutaneous Pathology”

This review discusses the changes in hair follicles with aging, particularly graying due to decreased melanocyte activity, and suggests potential for hair repigmentation under certain conditions, but reports no new results.

research Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

8 citations , April 2017 in “Journal of Dermatological Science”

The study found that aging in hair follicle stem cells leads to hair follicle miniaturization and eventual hair loss in both wild-type mice and humans by proteolyzing type XVII collagen.

research Single cell analysis of transcriptome and open chromatin reveals the dynamics of hair follicle stem cell aging

3 citations , July 2023 in “Frontiers in Aging”

This research detailed a single-cell atlas showing dynamic hair follicle stem cell states associated with the hair cycle during aging in mice, highlighting differences in chromatin landscape linked to stem cell differentiation and quiescence, and providing a foundation for future exploration of aging reversal.

research Aging of hair follicle stem cells and their niches

2 citations , November 2022 in “Journal of Biochemistry and Molecular Biology”

This review discusses how aging affects hair follicle stem cells and their environment, contributing to hair loss, and explores strategies to promote hair regrowth, but reports no new results.

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Community Join

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community Baldness Breakthrough: microRNA Stimulates Hair Growth in Aging Follicles

316 upvotes 3 years ago

miR-205, a tiny RNA, can stimulate hair growth by softening aging hair follicle stem cells in mice. Future tests aim to see if this can work in humans.

community Anyone here have a lot of knowledge on hair follicle stem cells and progenitor cells for PP405?

in Chat 4 upvotes 8 months ago

Hair follicle stem cells remain in bald individuals, but progenitor cells do not, raising questions about hair regrowth claims by Pelage. PP405 is discussed as a potential treatment, with skepticism about its effectiveness compared to existing treatments like Minoxidil and Finasteride.

community Intermittent fasting triggers hair loss in study (suppresses hair follicle regeneration)

in Research/Science 241 upvotes 7 months ago

Intermittent fasting may suppress hair follicle regeneration, but opinions vary on its impact on hair loss. Some users report no negative effects or even hair improvement while using treatments like finasteride and minoxidil.

community If PP405 does revive "dead" hair follicles would DHT blockers theoretically be enough to maintain that new hair

in Research/Science 115 upvotes 11 months ago

PP405 may revive dormant hair follicles, and DHT blockers like finasteride or dutasteride could maintain new hair. Combining PP405 with minoxidil might be optimal, but long-term effects and continuous use are uncertain.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

67 upvotes 11 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

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Learn

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learn Rapamycin

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

learn Dexpanthenol

precursor of vitamin B5 with hair stimulating effects

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

What role does Osteopontin play in protecting and repairing hair follicles? Osteopontin protects and repairs hair follicles by signaling cells to survive and recover.

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn Overview

learn Niacinamide

How does Niacinamide support the hair follicle’s nutrition? Niacinamide nourishes hair follicles by boosting energy production and supporting antioxidant defenses.

learn oleic acid

How does Oleic Acid support hair follicle strength and growth? Oleic acid strengthens hair follicles by enhancing hydration and reducing inflammation.

learn zinc PCA

Why is zinc important for preventing hair loss and supporting hair follicle function? Zinc is crucial for hair follicle health, supporting growth and repair processes.

learn Scalp Micropigmentation

Will scalp micropigmentation damage my existing hair or follicles? Scalp micropigmentation does not damage existing hair or follicles.

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Clinics

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All 38 clinic results →

Experts

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Unscored
SMP Specialist
Hairo Fallas
Newark, NJ, United States

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Hairo Fallas