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    Glossary Hair Follicle Aging

    gradual decline in hair follicle function and structure over time

    Hair Follicle Aging refers to the gradual decline in the function and structure of hair follicles over time. This process can lead to thinner, weaker hair, slower growth rates, and eventually hair loss. Factors contributing to hair follicle aging include genetic predisposition, hormonal changes, oxidative stress, and reduced cellular regeneration.

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    1. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis Science · 2016 · 242 citations
    2. Histopathology of aging of the hair follicle Journal of Cutaneous Pathology · 2019 · 31 citations
    3. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis Journal of Dermatological Science · 2017 · 8 citations
    4. Single cell analysis of transcriptome and open chromatin reveals the dynamics of hair follicle stem cell aging Frontiers in Aging · 2023 · 3 citations
    5. Aging of hair follicle stem cells and their niches Journal of Biochemistry and Molecular Biology · 2022 · 2 citations
    6. Targeting IGF1‐Induced Cellular Senescence to Rejuvenate Hair Follicle Aging Aging Cell · 2025
    7. Gas-propelled anti-hair follicle aging microneedle patch for the treatment of androgenetic alopecia Journal of Controlled Release · 2025
    8. 1431 Skin aging and hair follicle stem cell dysfunction caused by T cells with defective mitochondrial metabolism Journal of Investigative Dermatology · 2023
    9. Quiescent and aging hair follicle stem cells Science · 2016
    10. An efficient, non-invasive approach for in-vivo sampling of hair follicles: design and applications in monitoring DNA damage and aging Aging · 2021 · 12 citations
    11. P02 Accelerated ageing of hair follicles in androgenetic alopecia 2024
    12. Getting under the skin of hair aging: the impact of the hair follicle environment Experimental Dermatology · 2020 · 20 citations
    13. Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging Frontiers in Cell and Developmental Biology · 2021 · 5 citations
    14. 244 Defective maintenance of hair follicle stem cells through COL17A1 loss orchestrates the hair follicle aging program Journal of Investigative Dermatology · 2017
    15. Aging of the hair follicle pigmentation system International journal of trichology · 2009 · 75 citations
    16. Expression of anti-aging type-XVII collagen (COL17A1/BP180) in hair follicle-associated pluripotent (HAP) stem cells during differentiation Tissue & Cell · 2019 · 11 citations
    17. Towards a “free radical theory of graying”: melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage ˜The œFASEB journal · 2006 · 210 citations
    18. Combatting ageing in dermal papilla cells and promoting hair follicle regeneration using exosomes from human hair follicle dermal sheath cup cells Experimental Dermatology · 2023
    19. Aging in hair follicle stem cells and niche microenvironment The Journal of Dermatology · 2017 · 38 citations
    20. Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment 2016 · 11 citations
    21. Editorial: Hair Follicle Stem Cell Regeneration in Aging Frontiers in Cell and Developmental Biology · 2021 · 4 citations
    22. Spatiotemporal atlas resolves the mesenchymal-epithelial stem cell axis governing human hair follicle aging and pathology bioRxiv (Cold Spring Harbor Laboratory) · 2026
    23. Aging of hair follicle stem cells and their niche: mechanisms and regenerative therapeutic strategies Cell Communication and Signaling · 2026
    24. A Wnt5a-Cdc42 axis controls aging and rejuvenation of hair-follicle stem cells bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 5 citations
    25. Ageing processes influence keratin and KAP expression in human hair follicles Experimental Dermatology · 2011 · 35 citations
    26. Telomere Dynamics and Telomerase in the Biology of Hair Follicles and their Stem Cells as a Model for Aging Research Journal of Investigative Dermatology · 2021 · 12 citations
    27. Ageing and colony-forming efficiency of human hair follicle keratinocytes Experimental Dermatology · 2013 · 9 citations
    28. A Wnt5a-Cdc42 axis controls aging and rejuvenation of hair-follicle stem cells Research Square (Research Square) · 2020
    29. 022 Randomized, double-blind, placebo-controlled, single-centre, phase I safety study of intradermal injections of autologous fibroblasts isolated from the non-bulbar dermal sheath of the hair follicle to treat skin aging Journal of Investigative Dermatology · 2017
    30. 506 Taxane chemotherapy promotes aging of human hair follicles and their stem cells Journal of Investigative Dermatology · 2024