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research Conditional Knockout in Mice Reveals the Critical Roles of Ppp2ca in Epidermis Development

14 citations , May 2016 in “International Journal of Molecular Sciences”

This study showed that knocking out the Ppp2ca gene in the epidermis of mice led to significant hair loss and disrupted hair follicle morphogenesis and regeneration.

research [Construction and identification of mouse model with conditional knockout of p75 neurotrophin receptor gene in epidermal cells by Cre-loxP system].

1 citations , October 2019 in “PubMed”

This study successfully created a mouse model with conditional knockout of the p75 neurotrophin receptor gene in epidermis cells, with no significant changes in skin histomorphology observed.

research Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality

46 citations , December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that Acvr1b signaling is crucial for both hair follicle development and cycling in mice, with the genetic disruption leading to hair loss and a thickened epidermis.

research Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

242 citations , February 2016 in “Science”

This research found that Foxc1 transcription factor and COL17A1 are critical in regulating quiescence and hair thinning in hair follicle stem cells, with aging-related DNA damage leading to hair loss.

research Vitamin D and calcium signaling in epidermal stem cells and their regeneration

13 citations , July 2020 in “World journal of stem cells”

This review discusses vitamin D and calcium signaling roles in epidermal stem cell processes essential for wound healing but reports no new experimental results, emphasizing their potential interdependent regulatory mechanisms.

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community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 1 month ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

community Dutasteride likely reduces Bone Mineral Density

in Research/Science 5 months ago

Dutasteride may reduce bone mineral density, but there's no increased risk of osteoporosis or fractures compared to finasteride. Users suggest resistance training to counter potential bone effects.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Affordable shampoo and conditioner suggestions for long but thinning hair?

2 upvotes 11 months ago

A user with thinning, curly, dry hair is seeking affordable shampoo and conditioner recommendations. They are using oral minoxidil and apply argan oil, but dislike products with keratin and biotin, and another user suggests ketoconazole shampoo for added density and DHT blocking.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Thymosin Beta 4

learn Hair Transplant

What conditions can a hair transplant treat? Clinics say transplants can treat pattern baldness, long-inactive scarring alopecia and thinning; a transplant only moves hair a person still has, so the cause of the loss has to be diagnosed first.
Can I get a hair transplant if I have a medical condition? You may be eligible for a hair transplant, but consult a specialist first.

learn TDM-105795

What types of alopecia or hair loss conditions might TDM-105795 be designed to target based on current research? TDM-105795 may target non-scarring alopecia, particularly androgenetic alopecia.

learn Tofacitinib

What types of hair loss conditions are most commonly associated with tofacitinib use in clinical settings? Published studies link tofacitinib mainly to alopecia areata and its severe variants — as an off-label drug being studied for them, not as a cause of hair loss. The evidence is mostly small, open-label or retrospective, and relapse after stopping is commonly reported.

learn Omega 3

Does omega-3 help with scalp inflammation or irritation linked to conditions like dandruff or alopecia? Omega-3 may help reduce scalp inflammation linked to dandruff and alopecia.

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