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Glossary Transgenic Mice

mice with altered genomes to study specific gene effects

Transgenic mice, also known as genetically modified mice, are mice that have had their genomes altered through the introduction of foreign DNA. This genetic modification allows researchers to study the effects of specific genes on development, physiology, and disease, making them invaluable tools in biomedical research.

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Research

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research Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

409 citations , May 1991 in “Genes & Development”

This study observed that overexpression of TGF-alpha in transgenic mice led to thicker epidermis and stunted hair growth, particularly in regions with normally thick skin and low hair density.

research Interleukin 6: insights to its function in skin by overexpression in transgenic mice.

221 citations , June 1992 in “Proceedings of the National Academy of Sciences”

In this study, IL-6 expression in transgenic mice thickened the stratum corneum without causing increased epidermal proliferation or inflammation, suggesting it may enhance skin protection rather than directly induce inflammation.

research Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.

211 citations , February 1994 in “Proceedings of the National Academy of Sciences”

This study found that overexpression of parathyroid hormone-related peptide in transgenic mice skin disrupted normal hair follicle development, suggesting a role for the peptide in the early stages of follicle formation.

research Transgenic Mice Expressing IFN-γ in the Epidermis Have Eczema, Hair Hypopigmentation, and Hair Loss

150 citations , April 1997 in “Journal of Investigative Dermatology”

research Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development.

113 citations , May 2002 in “PubMed”

This study observed that COX-2 overexpression in transgenic mice led to a significant reduction in skin tumor development compared to controls, challenging the expected role of COX-2 in promoting tumors.

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community New study: Vitamin D counteracts DHT in mice and in human hair organ culture and hair cells

126 upvotes 1 year ago

Vitamin D may counteract DHT and help with hair growth, as seen in mice and human hair cultures. Some users discuss using Vitamin D, magnesium, and other supplements for hair health, while others humorously note the success in mice.

community Pilose antler extracts promotes hair growth in androgenetic alopecia mice by activating hair follicle stem cells via the AKT and Wnt pathways

11 upvotes 2 years ago

Pilose antler extracts may promote hair growth in androgenetic alopecia by activating hair follicle stem cells through the AKT and Wnt pathways. However, results in mice may not directly apply to humans due to differences in genetic and biochemical conditions.

community Is it possible to transplant mice skin into human body?

in Transplants 47 upvotes 11 months ago

Transplanting mice skin to humans is not feasible due to immune rejection, but some suggest genetic modification or immune suppression could make it possible. Xenograft hair transplants are discouraged.

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learn Thymosin Beta 4

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