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    Glossary Transgenic Mice

    mice with altered genomes to study specific gene effects

    Transgenic mice, also known as genetically modified mice, are mice that have had their genomes altered through the introduction of foreign DNA. This genetic modification allows researchers to study the effects of specific genes on development, physiology, and disease, making them invaluable tools in biomedical research.

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    1. Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes & Development · 1991 · 409 citations
    2. Interleukin 6: insights to its function in skin by overexpression in transgenic mice. Proceedings of the National Academy of Sciences · 1992 · 221 citations
    3. Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proceedings of the National Academy of Sciences · 1994 · 211 citations
    4. Transgenic Mice Expressing IFN-γ in the Epidermis Have Eczema, Hair Hypopigmentation, and Hair Loss Journal of Investigative Dermatology · 1997 · 150 citations
    5. Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development. PubMed · 2002 · 113 citations
    6. Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion. PubMed · 2000 · 99 citations
    7. Cyclic hair-loss and regrowth in transgenic mice overexpressing an intermediate filament gene. The EMBO Journal · 1990 · 93 citations
    8. Development of Heritable Melanoma in Transgenic Mice Journal of Investigative Dermatology · 1998 · 75 citations
    9. Promotion of Skin Carcinogenesis by Dimethylarsinic Acid in <i>Keratin (K6)/ODC</i> Transgenic Mice Japanese Journal of Cancer Research · 2000 · 48 citations
    10. Severe follicular hyperplasia and spontaneous papilloma formation in transgenic mice expressing theneu oncogene under the control of the bovine keratin 5 promoter Molecular Carcinogenesis · 1998 · 47 citations
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