Transgenic Mice Expressing IFN-γ in the Epidermis Have Eczema, Hair Hypopigmentation, and Hair Loss
April 1997
in “
Journal of Investigative Dermatology
”
Research cited in this study
2 / 2 results
research Cachexia and Graft-Versus-Host Disease-Type Skin Changes in Keratin Promoter-Driven TNF Alpha Transgenic Mice
This study reported that transgenic mice with targeted TNF alpha expression in keratinocytes showed impaired weight gain, retarded hair growth, and skin changes, leading to cachexia and necrosis.
research Transgenic Mice Provide New Insights Into the Role of TGF-Alpha During Epidermal Development and Differentiation
This study observed that overexpression of TGF-alpha in transgenic mice led to thicker epidermis and stunted hair growth, particularly in regions with normally thick skin and low hair density.
Related Research
3 / 3 results
research Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation
This study found that overexpressing Dsg3 in the suprabasal epidermis of transgenic mice resulted in flaking skin and abnormal hair growth, supporting Dsg3's role in regulating epidermal differentiation.
research Transgenic Mice Expressing IFN-γ in the Epidermis Have Eczema, Hair Hypopigmentation, and Hair Loss
research Overexpression of Human Keratin 16 Produces a Distinct Skin Phenotype in Transgenic Mouse Skin
This study found that high levels of human cytokeratin 16 expression in transgenic mice lead to skin lesions and altered keratinocyte structure, suggesting potential implications for human skin disorders and wound healing.