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    Glossary Transgenic Mice

    mice with altered genomes to study specific gene effects

    Transgenic mice, also known as genetically modified mice, are mice that have had their genomes altered through the introduction of foreign DNA. This genetic modification allows researchers to study the effects of specific genes on development, physiology, and disease, making them invaluable tools in biomedical research.

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    1. Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes & Development · 1991 · 409 citations
    2. Interleukin 6: insights to its function in skin by overexpression in transgenic mice. Proceedings of the National Academy of Sciences · 1992 · 221 citations
    3. Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proceedings of the National Academy of Sciences · 1994 · 211 citations
    4. Transgenic Mice Expressing IFN-γ in the Epidermis Have Eczema, Hair Hypopigmentation, and Hair Loss Journal of Investigative Dermatology · 1997 · 150 citations
    5. Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development. PubMed · 2002 · 113 citations
    6. Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion. PubMed · 2000 · 99 citations
    7. Cyclic hair-loss and regrowth in transgenic mice overexpressing an intermediate filament gene. The EMBO Journal · 1990 · 93 citations
    8. Development of Heritable Melanoma in Transgenic Mice Journal of Investigative Dermatology · 1998 · 75 citations
    9. Promotion of Skin Carcinogenesis by Dimethylarsinic Acid in <i>Keratin (K6)/ODC</i> Transgenic Mice Japanese Journal of Cancer Research · 2000 · 48 citations
    10. Severe follicular hyperplasia and spontaneous papilloma formation in transgenic mice expressing theneu oncogene under the control of the bovine keratin 5 promoter Molecular Carcinogenesis · 1998 · 47 citations
    11. A 5'-upstream region of a bovine keratin 6 gene confers tissue-specific expression and hyperproliferation-related induction in transgenic mice. Proceedings of the National Academy of Sciences · 1995 · 46 citations
    12. Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue Biochemical Journal · 1999 · 43 citations
    13. Epigen Transgenic Mice Develop Enlarged Sebaceous Glands Journal of Investigative Dermatology · 2009 · 33 citations
    14. Analysis of Sequences Controlling Tissue-Specific and Hyperproliferation-Related Keratin 6 Gene Expression in Transgenic Mice DNA and Cell Biology · 1998 · 26 citations
    15. Transgenic mice overexpressing CD109 in the epidermis display decreased inflammation and granulation tissue and improved collagen architecture during wound healing Wound Repair and Regeneration · 2013 · 22 citations
    16. Ornithine decarboxylase transgenic mice as a model for human atrichia with papular lesions Experimental dermatology · 2000 · 20 citations
    17. Transgenic Flash Mice for In Vivo Quantitative Monitoring of Canonical Wnt Signaling to Track Hair Follicle Cycle Dynamics Journal of Investigative Dermatology · 2014 · 16 citations
    18. Targeted expression of SV40 T antigen in the hair follicle of transgenic mice produces an aberrant hair phenotype Journal of cell science · 1995 · 14 citations
    19. Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue Biochemical Journal · 1999 · 13 citations
    20. The Human Papillomavirus Type 11 Upstream Regulatory Region Triggers Hair-Follicle-Specific Gene Expression in Transgenic Mice Journal of Investigative Dermatology · 1999 · 9 citations
    21. Growth retardation and hair loss in transgenic mice overexpressing human H-ferritin gene Transgenic Research · 2012 · 8 citations
    22. The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z‐protein in cells of the bulge region 1999 · 5 citations
    23. Chymase Activities and Survival in Endotoxin-Induced Human Chymase Transgenic Mice International Journal of Medical Sciences · 2014 · 3 citations
    24. Skin-specific transgenic overexpression of ovine β-catenin in mice Frontiers in Genetics · 2023 · 2 citations
    25. The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z-protein in cells of the bulge region 1999 · 2 citations
    26. 1386 Trichodysplasia spinulosa small T antigen drives ectopic hair follicle development in adult transgenic mice Journal of Investigative Dermatology · 2018 · 1 citations
    27. Transgenic mice display hair loss and regrowth overexpressing mutant <i>Hr</i> gene 2017
    28. Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature 2020 · 15 citations
    29. Homozygous K5Cre transgenic mice have wavy hair and accelerated malignant progression in a murine model of skin carcinogenesis Molecular Carcinogenesis · 2006 · 7 citations
    30. Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris Journal of Dermatological Science · 2011 · 17 citations