Inhibition of Metastatic Squamous Cell Carcinoma Development in Protein Kinase C Epsilon Transgenic Mice by Alpha-Difluoromethylornithine with Hair Follicle Degeneration and Hair Loss

    June 2003 in “ PubMed ”
    Deric L. Wheeler, Kristin J. Ness, Terry D. Oberley, Ajit Kumar Verma
    Studysummary In this study, severe hair loss occurred in PKC epsilon transgenic mice treated with DFMO during skin tumor prevention, highlighting a link between polyamine biosynthesis, hair follicle maintenance, and metastasis suppression.
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    Research cited in this study 5

    1. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    2. Transgenic Mice Overexpressing Protein Kinase C Epsilon in Their Epidermis Exhibit Reduced Papilloma Burden but Enhanced Carcinoma Formation After Tumor Promotion PubMed · 2000
    3. Overexpression of Protein Kinase C-α in the Epidermis of Transgenic Mice Results in Striking Alterations in Phorbol Ester-Induced Inflammation and COX-2, MIP-2, and TNF-α Expression but Not Tumor Promotion Journal of Cell Science · 1999
    4. Dynamic Expression of Ornithine Decarboxylase in Hair Growth Mechanisms of Development · 1999
    5. Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity Journal of Investigative Dermatology · 1996

    Related research 2

    1. Inhibition of Metastatic Squamous Cell Carcinoma Development in Protein Kinase C Epsilon Transgenic Mice by Alpha-Difluoromethylornithine with Hair Follicle Degeneration and Hair Loss PubMed · 2003
    2. Overexpression of Spermidine/Spermine N1-Acetyltransferase Under the Control of Mouse Metallothionein I Promoter in Transgenic Mice: Evidence for a Striking Post-Transcriptional Regulation of Transgene Expression by a Polyamine Analogue Biochemical Journal · 1999