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    Glossary Ornithine Decarboxylase

    enzyme converting ornithine to putrescine, crucial for cell growth

    Ornithine Decarboxylase (ODC) is an enzyme that plays a crucial role in cell growth and differentiation by catalyzing the conversion of ornithine to putrescine, a precursor for polyamines. These polyamines are essential for stabilizing DNA structure and promoting cell division. Elevated levels of ODC have been linked to conditions like cancer and hair loss, making it a significant target for therapeutic research.

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    1. Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin. PubMed · 1997 · 233 citations
    2. Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin Carcinogenesis · 1998 · 88 citations
    3. Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity Journal of Investigative Dermatology · 1996 · 71 citations
    4. A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis American Journal Of Pathology · 2001 · 67 citations
    5. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice Journal of Clinical Investigation · 2004 · 65 citations
    6. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice Journal of Clinical Investigation · 2004 · 64 citations
    7. Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 in Vivo Journal of Biological Chemistry · 1997 · 52 citations
    8. Ornithine decarboxylase is upregulated by the androgen receptor in skeletal muscle and regulates myoblast proliferation AJP Endocrinology and Metabolism · 2011 · 43 citations
    9. Heterogeneity of ornithine decarboxylase expression in 12-<i>O</i>-tetradecanoylphorbol-13-acetate-treated mouse skin and in epidermal tumors Carcinogenesis · 1986 · 37 citations
    10. Ornithine decarboxylase activity in relation to DNA synthesis in mouse interfollicular epidermis and hair follicles Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · 1975 · 34 citations
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