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GlossaryOrnithine Decarboxylase

enzyme converting ornithine to putrescine, crucial for cell growth

Ornithine Decarboxylase (ODC) is an enzyme that plays a crucial role in cell growth and differentiation by catalyzing the conversion of ornithine to putrescine, a precursor for polyamines. These polyamines are essential for stabilizing DNA structure and promoting cell division. Elevated levels of ODC have been linked to conditions like cancer and hair loss, making it a significant target for therapeutic research.

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research Ornithine Decarboxylase Overexpression Is a Sufficient Condition for Tumor Promotion in Mouse Skin

233 citations, July 1997 in “PubMed”

High levels of ornithine decarboxylase can cause tumors in mouse skin.

research Co-Operation Between Follicular Ornithine Decarboxylase and v-Ha-ras Induces Spontaneous Papillomas and Malignant Conversion in Transgenic Skin

88 citations, August 1998 in “Carcinogenesis”

High levels of ODC and a mutant Ha-ras gene cause tumors in mice.

research Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity

71 citations, May 1996 in “Journal of Investigative Dermatology”

Ornithine decarboxylase is crucial for hair growth regulation in mice.

research A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis

67 citations, September 2001 in “American Journal Of Pathology”

Inhibiting ODC can prevent UV-induced skin cancer.

research Ornithine Decarboxylase as a Target for Chemoprevention of Basal and Squamous Cell Carcinomas in Ptch1+/– Mice

65 citations, March 2004 in “Journal of Clinical Investigation”

Inhibiting ornithine decarboxylase may help prevent certain skin cancers.

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in Microneedling 19 upvotes 2 years ago

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