Search
for

    Glossary Ornithine Decarboxylase

    enzyme converting ornithine to putrescine, crucial for cell growth

    Ornithine Decarboxylase (ODC) is an enzyme that plays a crucial role in cell growth and differentiation by catalyzing the conversion of ornithine to putrescine, a precursor for polyamines. These polyamines are essential for stabilizing DNA structure and promoting cell division. Elevated levels of ODC have been linked to conditions like cancer and hair loss, making it a significant target for therapeutic research.

    Related Terms

    Sort by

    Research 30 of 345

    1. Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin. PubMed · 1997 · 233 citations
    2. Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin Carcinogenesis · 1998 · 88 citations
    3. Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity Journal of Investigative Dermatology · 1996 · 71 citations
    4. A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis American Journal Of Pathology · 2001 · 67 citations
    5. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice Journal of Clinical Investigation · 2004 · 65 citations
    6. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice Journal of Clinical Investigation · 2004 · 64 citations
    7. Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 in Vivo Journal of Biological Chemistry · 1997 · 52 citations
    8. Ornithine decarboxylase is upregulated by the androgen receptor in skeletal muscle and regulates myoblast proliferation AJP Endocrinology and Metabolism · 2011 · 43 citations
    9. Heterogeneity of ornithine decarboxylase expression in 12-<i>O</i>-tetradecanoylphorbol-13-acetate-treated mouse skin and in epidermal tumors Carcinogenesis · 1986 · 37 citations
    10. Ornithine decarboxylase activity in relation to DNA synthesis in mouse interfollicular epidermis and hair follicles Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · 1975 · 34 citations
    11. Ornithine decarboxylase expression in cutaneous papillomas in SENCAR mice is associated with altered expression of keratins 1 and 10. PubMed · 1994 · 33 citations
    12. Conversion of C57Bl/6 mice from a tumor promotion-resistant to a -sensitive phenotype by enhanced ornithine decarboxylase expression Molecular Carcinogenesis · 1999 · 31 citations
    13. Induction of ornithine decarboxylase in specific subpopulations of murine epidermal cells following multiple exposures to 12-<i>O</i>-tetradecanoylphorbol-13-acetate, mezerein and ethyl phenylpropriolate Carcinogenesis · 1992 · 26 citations
    14. Dynamic expression of ornithine decarboxylase in hair growth Mechanisms of Development · 1999 · 24 citations
    15. Ornithine decarboxylase transgenic mice as a model for human atrichia with papular lesions Experimental dermatology · 2000 · 20 citations
    16. Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites Amino Acids · 2013 · 17 citations
    17. A Simple In Vivo System for Studying Epithelialization, Hair Follicle Formation, and Invasion Using Primary Epidermal Cells from Wild-Type and Transgenic Ornithine Decarboxylase-Overexpressing Mouse Skin Journal of Investigative Dermatology · 2001 · 13 citations
    18. Induction of ornithine decarboxylase activity in hairless rat epidermis as a pharmacological model: validation of the animal model Laboratory Animals · 1987 · 4 citations
    19. Antizyme Release Is an Early Event in Ornithine Decarboxylase Induction by Hair Plucking Journal of Investigative Dermatology · 1983 · 3 citations
    20. Role of Ornithine Decarboxylase in Human Hair Follicles 2010 · 1 citations
    21. Epidermal cell proliferation and modulation of the protective potency of dexamethasone against phorbol ester-induced ornithine decarboxylase activity Carcinogenesis · 1989 · 1 citations
    22. Conversion of C57Bl/6 mice from a tumor promotion–resistant to a –sensitive phenotype by enhanced ornithine decarboxylase expression Molecular Carcinogenesis · 1999
    23. Association of a polymorphism in the ornithine decarboxylase gene with male androgenetic alopecia Journal of The American Academy of Dermatology · 2005 · 5 citations
    24. [Studies on enzyme activities in the hair root in male pattern baldness: glycolytic enzyme, acid hydrolase, transglutaminase and ornithine decarboxylase activities of plucked hair roots]. PubMed · 1985
    25. Topical Eflornithine American journal of clinical dermatology · 2001 · 115 citations
    26. K6/ODC transgenic mice as a sensitive model for carcinogen identification Toxicology Letters · 2000 · 57 citations
    27. Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase Journal of Investigative Dermatology · 2001 · 54 citations
    28. Promotion of Skin Carcinogenesis by Dimethylarsinic Acid in <i>Keratin (K6)/ODC</i> Transgenic Mice Japanese Journal of Cancer Research · 2000 · 48 citations
    29. BIOCHEMICAL ANALYSIS OF HAIR GROWTH FROM THE ASPECTS OF AGING AND ENZYME ACTIVITIES The Journal of Dermatology · 1983 · 46 citations
    30. Inhibition of Polyamine Synthesis Alters Hair Follicle Function and Fiber Composition Journal of Investigative Dermatology · 1996 · 42 citations