Ornithine Decarboxylase as a Target for Chemoprevention of Basal and Squamous Cell Carcinomas in Ptch1+/– Mice

    March 2004 in “ Journal of Clinical Investigation ”
    Xiuwei Tang, Arianna L. Kim, David J. Feith … Mohammad Athar
    Studysummary This study found that inhibiting the enzyme ornithine decarboxylase (ODC) prevented UVB-induced basal cell carcinomas in a mouse model, suggesting ODC is a potential target for chemoprevention strategies.
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    Research cited in this study 6

    1. Inhibition of Metastatic Squamous Cell Carcinoma Development in Protein Kinase C Epsilon Transgenic Mice by Alpha-Difluoromethylornithine with Hair Follicle Degeneration and Hair Loss PubMed · 2003
    2. A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis American Journal Of Pathology · 2001
    3. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    4. Co-Operation Between Follicular Ornithine Decarboxylase and v-Ha-ras Induces Spontaneous Papillomas and Malignant Conversion in Transgenic Skin Carcinogenesis · 1998
    5. Analysis of Sequences Controlling Tissue-Specific and Hyperproliferation-Related Keratin 6 Gene Expression in Transgenic Mice DNA and Cell Biology · 1998
    6. Ornithine Decarboxylase Overexpression Is a Sufficient Condition for Tumor Promotion in Mouse Skin PubMed · 1997

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    3. Molecular Conversations and the Development of the Hair Follicle and Basal Cell Carcinoma Cancer Prevention Research · 2010
    4. Ornithine Decarboxylase as a Target for Chemoprevention of Basal and Squamous Cell Carcinomas in Ptch1+/– Mice Journal of Clinical Investigation · 2004
    5. Dynamic Expression of Ornithine Decarboxylase in Hair Growth Mechanisms of Development · 1999
    6. Ornithine Decarboxylase Overexpression Is a Sufficient Condition for Tumor Promotion in Mouse Skin PubMed · 1997
    7. Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity Journal of Investigative Dermatology · 1996