Keratin-6 Driven ODC Expression in Hair Follicle Keratinocytes Enhances Stemness and Tumorigenesis by Negatively Regulating Notch

    August 2014 in “ Biochemical and Biophysical Research Communications ”
    Aadithya Arumugam, Zhiping Weng, Sandeep Chaudhary, Farrukh Afaq, Craig A. Elmets, Mohammad Athar
    TLDR ODC overexpression in hair cells increases tumor growth by reducing Notch signaling.
    The study explored the impact of ornithine decarboxylase (ODC) overexpression in hair follicle keratinocytes on stem cell behavior and tumorigenesis, particularly its interaction with Notch signaling. Using two mouse models, K6-ODC/SKH-1 and K14-ODC/SKH-1, it was found that ODC overexpression in K6-ODC/SKH-1 mice led to a significant increase in tumor development and invasiveness, with 15±2.5 tumors per mouse compared to 6.8±1.5 in K14-ODC/SKH-1 mice. This was linked to an expansion of the stem cell compartment and a down-regulation of Notch signaling, suggesting that ODC may enhance skin carcinogenesis by promoting stem-like cancer-initiating cells and contributing to invasive squamous cell carcinomas.
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