Dynamic Expression of Ornithine Decarboxylase in Hair Growth

    June 1999 in “ Mechanisms of Development
    Michelle J. Nancarrow, Antonietta Nesci, PI Hynd, Barry C. Powell
    TLDR Ornithine decarboxylase is crucial for hair growth and follicle development.
    The study investigated the role of ornithine decarboxylase (ODC) in hair follicles, revealing its importance in hair growth and follicle development. ODC, essential for polyamine synthesis, was crucial for hair growth, as its inhibition resulted in decreased hair growth and alopecia in various animals. The research showed that ODC expression was significant during the anagen phase of the hair cycle, especially in the follicle bulb, but absent in the catagen and telogen phases. Additionally, ODC was linked to cell proliferation and was vital during embryonic follicle development, indicating its significant role in hair follicle function and hair growth processes.
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