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GlossaryOrnithine Decarboxylase (ODC)

enzyme converting ornithine to putrescine, crucial for cell growth

Ornithine Decarboxylase (ODC) is an enzyme that plays a crucial role in cell growth and differentiation by catalyzing the conversion of ornithine to putrescine, a precursor for polyamines. These polyamines are essential for stabilizing DNA structure and promoting cell division. Elevated levels of ODC have been linked to conditions like cancer and hair loss, making it a significant target for therapeutic research.

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research K6/ODC transgenic mice as a sensitive model for carcinogen identification

57 citations, July 2000 in “Toxicology Letters”

research Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis

37 citations, January 2006 in “Carcinogenesis”

research Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch

8 citations, August 2014 in “Biochemical and Biophysical Research Communications”

research Promotion of Skin Carcinogenesis by Dimethylarsinic Acid in Keratin (K6)/ODC Transgenic Mice

48 citations, June 2000 in “Japanese Journal of Cancer Research”

research A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis

67 citations, September 2001 in “American Journal Of Pathology”

Inhibiting ODC can prevent UV-induced skin cancer.

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