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GlossaryOrnithine Decarboxylase (ODC)

enzyme converting ornithine to putrescine, crucial for cell growth

Ornithine Decarboxylase (ODC) is an enzyme that plays a crucial role in cell growth and differentiation by catalyzing the conversion of ornithine to putrescine, a precursor for polyamines. These polyamines are essential for stabilizing DNA structure and promoting cell division. Elevated levels of ODC have been linked to conditions like cancer and hair loss, making it a significant target for therapeutic research.

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research Tumor Suppressor Activity of ODC Antizyme in MEK-Driven Skin Tumorigenesis

37 citations , January 2006 in “Carcinogenesis”

Antizyme slows skin tumor growth by reducing cell growth in mice.

research Keratin-6 Driven ODC Expression in Hair Follicle Keratinocytes Enhances Stemness and Tumorigenesis by Negatively Regulating Notch

8 citations , August 2014 in “Biochemical and Biophysical Research Communications”

ODC overexpression in hair cells increases tumor growth by reducing Notch signaling.

research K6/ODC Transgenic Mice as a Sensitive Model for Carcinogen Identification

57 citations , July 2000 in “Toxicology Letters”

K6/ODC transgenic mice are effective for quickly identifying cancer-causing chemicals.

research Promotion of Skin Carcinogenesis by Dimethylarsinic Acid in Keratin (K6)/ODC Transgenic Mice

48 citations , June 2000 in “Japanese Journal of Cancer Research”

Dimethylarsinic acid speeds up skin tumor growth in certain mice.

research Co-Operation Between Follicular Ornithine Decarboxylase and v-Ha-ras Induces Spontaneous Papillomas and Malignant Conversion in Transgenic Skin

88 citations , August 1998 in “Carcinogenesis”

High levels of ODC and a mutant Ha-ras gene cause tumors in mice.

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