research A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis
Inhibiting ODC can prevent UV-induced skin cancer.
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30 / 95 resultsresearch Gain-Of-Function Variants In The ODC1 Gene Cause A Syndromic Neurodevelopmental Disorder Associated With Macrocephaly, Alopecia, Dysmorphic Features, And Neuroimaging Abnormalities
ODC1 gene mutations cause a neurodevelopmental disorder with large head size, hair loss, and facial abnormalities.
research Ornithine Decarboxylase Transgenic Mice as a Model for Human Atrichia with Papular Lesions
ODC transgenic mice can model human hair loss with skin lesions.
research Biochemical Features of Primary Cells from a Pediatric Patient with a Gain-of-Function ODC1 Genetic Mutation
A new genetic disorder caused by an ODC1 mutation can be treated with DFMO.
research Polyamines and Hair: A Couple in Search of Perfection
Polyamines are important for hair growth, but more research is needed to understand their functions and treatment potential.
research Characteristics of Flutamide Action on Prostatic and Testicular Functions in the Rat
Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.
research Regulation Mechanisms of Hair Growth
Hair regrowth slows with age and can be affected by treatments that change enzyme activity in the skin.
research Expanding the Phenotype: Four New Cases and Hope for Treatment in Bachmann-Bupp Syndrome
Four new cases of Bachmann-Bupp syndrome suggest potential for targeted treatment.
research Commentary on: Hairless and the Polyamine Putrescine Form a Negative Regulatory Loop in the Epidermis
The commentary explains that a balance of HR protein and putrescine is important for normal hair growth.
research Green Tea Extract: A Novel Addition to the Antihirsutism Armamentarium?
Green tea extract may help reduce excessive hair growth.
research Drug Discovery Today: Therapeutic Strategies - 2006 Editorial
The 2006 editorial concluded that immunotherapy was advancing with new drugs, focusing on specific biological therapies and convenient oral treatments, and highlighted the importance of partnerships and new regulations in the field.
research Bachmann–Bupp Syndrome and Treatment
DFMO treatment improves hair growth, muscle tone, and development in Bachmann-Bupp syndrome patients.
research Increased Hair Polyamine Levels in Patients with Alzheimer's Disease
Alzheimer's patients have higher levels of certain chemicals in their hair.
research Development and Homeostasis of the Sebaceous Gland
The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.
research The Hairless Gene of the Mouse: Relationship of Phenotypic Effects with Expression Profile and Genotype
Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.
research Promotion of Homology-Directed DNA Repair by Polyamines
Polyamines help fix DNA damage accurately in cells.
research Cutaneous Application of Alpha-Methylspermidine Activates the Growth of Resting Hair Follicles in Mice
Putting α-methylspermidine on mouse skin can start hair growth.
research Association of a Polymorphism in the Ornithine Decarboxylase Gene with Male Androgenetic Alopecia
research Serendipity in Trichology
Accidental findings have led to new hair treatment discoveries, like using blood pressure and diabetes medications for hair loss and unwanted hair.
research Chapter 20: Advances in Dermatological Treatments
New treatments for skin diseases are more effective and patient-friendly, but many still lack a cure.
research CRISPR/Cas9-Based Targeted Genome Editing for Correction of Recessive Dystrophic Epidermolysis Bullosa Using iPS Cells
The research showed that CRISPR/Cas9 can fix mutations causing a skin disease in stem cells, which then improved skin grafts in mice, but more work on safety and efficiency is needed.
research Different Polyamine Levels in the Vertex and Occipital Hair of Pattern Hair Loss Patients
People with pattern hair loss have higher polyamine levels in the top of their head compared to the back.
research Molecular Genetic Dissection of ILVEN Leads to Successful Targeted Therapy
Targeted therapy with Ustekinumab significantly improved a skin condition called ILVEN, which is caused by mutations in the CARD14 gene.
research Specialized Ribosomes in Human Dermal Fibroblast Senescence
Specialized ribosomes affect aging in human skin cells.
research Visually Scoring Hirsutism
The modified Ferriman-Gallwey method is a useful tool for diagnosing hirsutism.
research APCDD1 Is a Novel Wnt Inhibitor Mutated in Hereditary Hypotrichosis Simplex
A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.
research Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: Annotated Tables
Mutant mice help researchers understand hair growth and related genetic factors.
research Inhibition of Skin 5α-Reductase by Oral Contraceptive Progestins In Vitro
Norgestimate is the most effective birth control progestin for reducing an enzyme linked to acne and excessive hair growth in women.
research Effect of Minoxidil on Cultured Keratinocytes
Minoxidil helps hair cells live longer and grow longer.
research Fadrozole And Finasteride Exposures Modulate Sex Steroid- And Thyroid Hormone-Related Gene Expression In Silurana (Xenopus) Tropicalis Early Larval Development
Fadrozole and finasteride change gene expression related to sex hormones and thyroid hormones in frog larvae development.