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    Glossary Ornithine Decarboxylase Inhibitors

    compounds that block an enzyme crucial for cell growth

    Ornithine Decarboxylase Inhibitors (ODC Inhibitors) are compounds that block the activity of the enzyme ornithine decarboxylase, which is crucial for the production of polyamines. Polyamines are molecules that play a key role in cell growth and differentiation. By inhibiting this enzyme, ODC Inhibitors can potentially slow down or prevent the proliferation of cells, making them useful in treatments for conditions like cancer and certain types of hair loss, such as androgenetic alopecia.

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    Research 10 of 334

    1. A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis American Journal Of Pathology · 2001 · 67 citations
    2. Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin Carcinogenesis · 1998 · 88 citations
    3. Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity Journal of Investigative Dermatology · 1996 · 71 citations
    4. Comprehensive clinical management of hirsutism Gynecological endocrinology · 2010 · 14 citations
    5. Contemporary medical therapy for polycystic ovary syndrome International journal of gynaecology and obstetrics · 2006 · 31 citations
    6. Antizyme Release Is an Early Event in Ornithine Decarboxylase Induction by Hair Plucking Journal of Investigative Dermatology · 1983 · 3 citations
    7. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice Journal of Clinical Investigation · 2004 · 65 citations
    8. Role of Ornithine Decarboxylase in Human Hair Follicles 2010 · 1 citations
    9. Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. PubMed · 2003 · 26 citations
    10. Topical Eflornithine American journal of clinical dermatology · 2001 · 115 citations
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