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    Glossary Ornithine Decarboxylase Inhibitors

    compounds that block an enzyme crucial for cell growth

    Ornithine Decarboxylase Inhibitors (ODC Inhibitors) are compounds that block the activity of the enzyme ornithine decarboxylase, which is crucial for the production of polyamines. Polyamines are molecules that play a key role in cell growth and differentiation. By inhibiting this enzyme, ODC Inhibitors can potentially slow down or prevent the proliferation of cells, making them useful in treatments for conditions like cancer and certain types of hair loss, such as androgenetic alopecia.

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    Research 30 of 334

    1. A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis American Journal Of Pathology · 2001 · 67 citations
    2. Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin Carcinogenesis · 1998 · 88 citations
    3. Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity Journal of Investigative Dermatology · 1996 · 71 citations
    4. Comprehensive clinical management of hirsutism Gynecological endocrinology · 2010 · 14 citations
    5. Contemporary medical therapy for polycystic ovary syndrome International journal of gynaecology and obstetrics · 2006 · 31 citations
    6. Antizyme Release Is an Early Event in Ornithine Decarboxylase Induction by Hair Plucking Journal of Investigative Dermatology · 1983 · 3 citations
    7. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice Journal of Clinical Investigation · 2004 · 65 citations
    8. Role of Ornithine Decarboxylase in Human Hair Follicles 2010 · 1 citations
    9. Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. PubMed · 2003 · 26 citations
    10. Topical Eflornithine American journal of clinical dermatology · 2001 · 115 citations
    11. Synergy of Eflornithine Cream with Laser and Light-Based Systems for Hair Management Elsevier eBooks · 2009 · 1 citations
    12. Aktuelle Therapie der Hypertrichosen Der Hautarzt · 2001 · 6 citations
    13. Serendipity in Trichology International Journal of Trichology · 2011 · 4 citations
    14. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice Journal of Clinical Investigation · 2004 · 64 citations
    15. Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 in Vivo Journal of Biological Chemistry · 1997 · 52 citations
    16. Dynamic expression of ornithine decarboxylase in hair growth Mechanisms of Development · 1999 · 24 citations
    17. Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites Amino Acids · 2013 · 17 citations
    18. Ornithine decarboxylase is upregulated by the androgen receptor in skeletal muscle and regulates myoblast proliferation AJP Endocrinology and Metabolism · 2011 · 43 citations
    19. Polyamines and hair: a couple in search of perfection Experimental Dermatology · 2010 · 30 citations
    20. Green Tea Extract: A Novel Addition to the Antihirsutism Armamentarium? 2009 · 3 citations
    21. Vaniqa--eflornithine 13.9% cream. PubMed · 2001 · 34 citations
    22. Hypertrichosis and hirsutism Therapeutische Umschau · 2002
    23. K6/ODC transgenic mice as a sensitive model for carcinogen identification Toxicology Letters · 2000 · 57 citations
    24. Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase Journal of Investigative Dermatology · 2001 · 54 citations
    25. Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch Biochemical and Biophysical Research Communications · 2014 · 8 citations
    26. Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis Experimental Dermatology · 2013 · 10 citations
    27. The remarkable legacy of the K6/ODC mouse: mechanisms of polyamine-promoted tumorigenesis revealed Amino Acids · 2026
    28. Capryloyl glycine and soy isoflavonoids in hypertrichosis: An experimental and placebo‐controlled clinical study Journal of Cosmetic Dermatology · 2021 · 1 citations
    29. Diagnosis and treatments of hirsutism: where are we? Expert Review of Dermatology · 2011 · 3 citations
    30. Idiopathic Hirsutism* Endocrine Reviews · 2000 · 47 citations