Interventional Studies for Polycystic Ovarian Syndrome in Children and Adolescents

January 2010 in “ Pediatric Health ”

Patricia Vuguin

polycystic ovarian syndrome PCOS insulin-sensitizing medications weight reduction exercise oral contraceptive pills antiandrogens insulin sensitizers metformin birth control pills

Studysummary This review discusses treatment strategies for PCOS, focusing on using insulin-sensitizing medications alongside weight reduction and exercise to improve hyperinsulinemia and hyperandrogenism, and reports no new results.

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research Visually Scoring Hirsutism

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This review examines various methods for assessing hair growth in women, highlighting the usefulness of the mFG visual scoring method for diagnosing hirsutism despite its limitations.

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

1540 citations , October 2008 in “Fertility and Sterility”

This review discusses the definition of polycystic ovary syndrome proposed by the AE-PCOS Society Task Force, emphasizing hyperandrogenism, ovarian dysfunction, and excluding related disorders, while noting potential variations needing more research.

research What Every Physician Should Know About Polycystic Ovary Syndrome

33 citations , September 2008 in “Dermatologic therapy”

This review describes the clinical evaluation and management options for women with polycystic ovary syndrome, focusing on its endocrine and metabolic implications, but reports no new results.

research Polycystic Ovary Syndrome in Adolescence

85 citations , June 2008 in “Annals of the New York Academy of Sciences”

This article proposes a hypothesis that hyperandrogenemia is the final common pathway for developing adolescent PCOS and emphasizes the importance of reducing androgen levels to mitigate risks of metabolic syndrome, diabetes, and infertility in adulthood.

research Use of Ethinylestradiol/Drospirenone Combination in Patients with Polycystic Ovary Syndrome

52 citations , April 2008 in “Therapeutics and clinical risk management”

This review covers the use of combined oral contraceptives, particularly drospirenone, for managing polycystic ovary syndrome and discusses related metabolic controversies without reporting new clinical results.

Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

research Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

1744 citations , August 2006 in “The Journal of Clinical Endocrinology and Metabolism”

This review discusses definitions of polycystic ovary syndrome and reports no new clinical results; the authors support using modified 1990 NIH criteria and acknowledge ongoing evolution as research advances.

research Treatment of Hirsutism and Acne in Hyperandrogenism

54 citations , June 2006 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

This review discusses the management of hirsutism and acne in women with polycystic ovary syndrome, highlighting the partial effectiveness of current treatments and suggesting a combined approach of medication and hair removal.

research Guidance for the Management of Hirsutism

39 citations , July 2005 in “Current medical research and opinion”

This article discusses available methods for managing excessive facial hair growth in women and mentions that eflornithine 11.5% cream can reduce hair growth and the frequency of removal, but it reports no new clinical findings.

research Current Evaluation of Amenorrhea

21 citations , September 2004 in “Fertility and Sterility”

Amenorrhea, or the absence of periods, should be evaluated by age 15 or within five years of early breast development, and is most commonly caused by conditions like polycystic ovary syndrome and hypothalamic amenorrhea.

research Hirsutism and Acne in Polycystic Ovary Syndrome

169 citations , August 2004 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology”

This article discusses treatments for hirsutism and acne in women with polycystic ovary syndrome, suggesting that lower doses of current medications maintain efficacy while reducing cost and side effects, but reports no new clinical results.

research The Evaluation and Management of Hirsutism

195 citations , May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology”

This review discusses the diagnosis and treatment of hirsutism, emphasizing that a systematic evaluation can determine its cause, while combination therapy effectively manages the condition for most patients.

research Adult Polycystic Ovary Syndrome Begins in Childhood

124 citations , June 2002 in “Best Practice & Research Clinical Endocrinology & Metabolism”

This article reviews polycystic ovary syndrome in adolescents, highlighting its endocrine and metabolic features, and reports no new clinical findings; the etiology may involve early-life abnormalities in androgen production.

Receiver Operating Characteristic Analysis of the Performance of Basal Serum Hormone Profiles for the Diagnosis of Polycystic Ovary Syndrome in Epidemiological Studies

research Receiver Operating Characteristic Analysis of the Performance of Basal Serum Hormone Profiles for the Diagnosis of Polycystic Ovary Syndrome in Epidemiological Studies

66 citations , November 2001 in “European journal of endocrinology”

This study suggests that decreased SHBG levels and increased FAI, free testosterone, and DHEAS concentrations are effective in diagnosing PCOS in epidemiological studies of women of reproductive age.

research Topical Eflornithine: Efficacy in Reducing Unwanted Facial Hair Growth in Women

115 citations , January 2001 in “American journal of clinical dermatology”

This study found that eflornithine 15% cream reduced unwanted facial hair growth more effectively than a placebo in women with hirsutism, but hair growth returned to pretreatment levels within 8 weeks of stopping treatment.

research Comparison of Finasteride Versus Flutamide in the Treatment of Hirsutism

75 citations , October 1999 in “European journal of endocrinology”

This study found that both finasteride and flutamide effectively reduce hirsutism in women with polycystic ovary syndrome or idiopathic hirsutism, but flutamide was more effective.

research Prevalence of Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study

378 citations , September 1998 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that the prevalence of PCOS in a population of unselected U.S. women was 4.0%, with no significant racial differences between White and Black women.

research Adolescent Polycystic Ovary Syndrome

35 citations , June 1997 in “Annals of the New York Academy of Sciences”

Early diagnosis and multidisciplinary care are crucial for managing PCOS in adolescents.

research Effect of a Combination of Ethinylestradiol and Desogestrel in Adolescents with Oligomenorrhea and Ovarian Hyperandrogenism

5 citations , July 1987 in “European Journal of Obstetrics & Gynecology and Reproductive Biology”

This study found that a combined oral contraceptive containing ethinyl estradiol and desogestrel appeared effective in temporarily treating ovarian hyperandrogenism in adolescents, with reductions in hormone levels and ovarian volume observed.