Interventional Studies for Polycystic Ovarian Syndrome in Children and Adolescents

The document from 2010 reviews the challenges and treatments for polycystic ovarian syndrome (PCOS) in children and adolescents. It outlines the prevalence of PCOS, its association with metabolic and cardiovascular abnormalities, and the complexity of its diagnosis during puberty. The review discusses the use of insulin-sensitizing medications, weight reduction, and exercise to manage symptoms, and emphasizes the importance of early diagnosis and treatment to prevent long-term complications. It also covers the use of oral contraceptive pills, antiandrogens, and insulin sensitizers like metformin for managing PCOS, noting the need for lifestyle modifications alongside medication. The document calls for further research into the long-term effects of PCOS treatments starting in childhood and the development of additional diagnostic criteria and screening protocols for at-risk adolescents. However, it does not provide specific numbers of participants, as it is a review rather than a study with a defined participant group.