Polycystic Ovary Syndrome in Adolescence

    June 2008 in “ Annals of the New York Academy of Sciences ”
    Susan K. Blank, Kristin D. Helm, Christopher R. McCartney, John C. Marshall
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    TLDR PCOS starts in adolescence with hormonal issues, leading to adult health problems, and early treatment is crucial.
    The 2008 document discusses Polycystic Ovary Syndrome (PCOS) in adolescents, highlighting that hormonal abnormalities like hyperinsulinemia and rapid luteinizing hormone (LH) pulse frequency begin in adolescence and contribute to the overproduction of androgens. Hyperandrogenemia (HA) is identified as a central factor in PCOS development, leading to metabolic syndrome, diabetes, and infertility in adulthood. Clinical features such as hirsutism, acne, and menstrual dysfunction are common, with varying prevalence. The paper underscores the importance of early recognition and management of PCOS to prevent long-term complications and discusses treatment options like lifestyle changes, oral contraceptive pills, insulin sensitizers, and antiandrogens. It also calls for more research to identify individuals at risk for HA and its negative outcomes.
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