Compendium of Polycystic Ovarian Syndrome and Its Relevance in Glycation and Diabetes

    January 2022 in “ Journal of experimental and clinical medicine ”
    Payal Poojari, Amruta PADGAONKAR, Additiya Paramanya, Ahmad H. Ali
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    TLDR PCOS is linked to diabetes and insulin resistance, and managing AGEs may help treat related symptoms.
    Polycystic Ovarian Syndrome (PCOS) is closely linked with metabolic disorders such as Type 2 Diabetes Mellitus (T2DM), with insulin resistance (IR) being a central factor. The review highlights the connection between PCOS, IR, and the formation of advanced glycation end products (AGEs), which contribute to IR and can worsen PCOS and diabetes symptoms. It suggests that targeting the interaction between AGEs and their receptors (RAGE) may help in managing IR-related complications. The document also discusses the potential benefits of M. oleifera and S. platensis in providing symptomatic relief for PCOS and mentions common medications like metformin, inositol, thiazolidinediones, and spironolactone used for treatment. The review underscores the complex relationship between hormonal imbalances and metabolic dysfunctions in PCOS.
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