TLDR Polycystic Ovary Syndrome likely starts in childhood and may be genetic and influenced by early hormone exposure.
The 2002 document discusses Polycystic Ovary Syndrome (PCOS), a common endocrine disorder in women that may originate in childhood or fetal development. It is characterized by hypersecretion of androgens and luteinizing hormone, insulin resistance, and is a significant risk factor for type 2 diabetes. The document suggests that genetic factors, such as gene polymorphisms, may contribute to PCOS, and that fetal exposure to high levels of androgens could lead to the development of the syndrome. It emphasizes the importance of early recognition and management of PCOS to prevent its various consequences and recommends treatments such as cyclical progestagens, oral contraceptives, anti-androgens, and possibly insulin-sensitizing drugs. The document concludes that while the exact cause of PCOS is unclear, it likely has a genetic basis and may be influenced by early exposure to androgens.
39 citations,
September 2000 in “Obstetrics and Gynecology Clinics of North America” Insulin-lowering medications show promise for PCOS symptoms but can't be the main treatment yet due to limited long-term research.
1947 citations,
September 1995 in “New England journal of medicine/The New England journal of medicine” PCOS is a common hormonal disorder causing irregular periods and increased hair growth, linked to insulin resistance and long-term health issues.
195 citations,
November 2019 in “Clinica Chimica Acta” High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.
60 citations,
September 2001 in “Journal of the American Academy of Dermatology” Insulin resistance contributes to hormone imbalances in many women with polycystic ovary syndrome.
15 citations,
January 2015 in “Clinical and Experimental Reproductive Medicine” Taiwanese women with PCOS experience different symptoms based on age, with younger women facing more hormone imbalances and older women dealing with more metabolic issues.
96 citations,
February 2007 in “The Journal of Clinical Endocrinology & Metabolism” Women with type 1 diabetes often have polycystic ovary syndrome and excess male hormones, which are frequently undiagnosed.
9 citations,
January 2007 in “Gynecological Endocrinology” A woman was the first known case to have both polycystic ovary syndrome and autoimmune polyglandular syndrome type 2, suggesting a need to check for both conditions in similar patients.
Women with Polycystic Ovary Syndrome (PCOS) have a higher risk of developing type 2 diabetes due to insulin resistance.
