Adult Polycystic Ovary Syndrome Begins in Childhood

The 2002 document discusses Polycystic Ovary Syndrome (PCOS), a common endocrine disorder in women that may originate in childhood or fetal development. It is characterized by hypersecretion of androgens and luteinizing hormone, insulin resistance, and is a significant risk factor for type 2 diabetes. The document suggests that genetic factors, such as gene polymorphisms, may contribute to PCOS, and that fetal exposure to high levels of androgens could lead to the development of the syndrome. It emphasizes the importance of early recognition and management of PCOS to prevent its various consequences and recommends treatments such as cyclical progestagens, oral contraceptives, anti-androgens, and possibly insulin-sensitizing drugs. The document concludes that while the exact cause of PCOS is unclear, it likely has a genetic basis and may be influenced by early exposure to androgens.