Polycystic Ovarian Syndrome: Correlation Between Hyperandrogenism, Insulin Resistance, and Obesity

    November 2019 in “ Clinica Chimica Acta ”
    Xin Zeng, Yuanjie Xie, Yating Liu, Shuang-lian Long, Mo Zhang
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    TLDR High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.
    The document from March 1, 2020, reviews the relationship between hyperandrogenism, insulin resistance, and obesity in polycystic ovary syndrome (PCOS), emphasizing the vicious cycle they create that exacerbates the condition. It explains that hyperandrogenism affects follicular development and is linked to obesity and insulin resistance, with dysregulation of steroidogenic enzymes contributing to PCOS. The review also notes that treatments like oral contraceptive pills and insulin-sensitizing drugs can improve symptoms by decreasing androgen levels. Despite the availability of treatments to manage symptoms, the exact pathogenic mechanisms of PCOS are still not fully understood, and further research is necessary to develop more effective therapies. The document also mentions that while interventions like electro-acupuncture and physical exercise can alleviate symptoms, a deeper understanding of PCOS pathophysiology is needed for better treatment development.
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