Contemporary Medical Therapy for Polycystic Ovary Syndrome

    September 2006 in “ International journal of gynaecology and obstetrics ”
    Michael Lanham, Dan I. Lebovic, Steven E. Domino
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    TLDR New treatments for PCOS focus on insulin resistance and reducing testosterone levels, along with traditional hormone therapies.
    The document from 2006 discusses Polycystic ovary syndrome (PCOS), a complex endocrine disorder with significant long-term metabolic and cardiovascular implications. It is diagnosed based on two of three criteria: chronic oligoovulation or anovulation, evidence of hyperandrogenism, and polycystic ovaries on ultrasound. Traditional treatments for PCOS include oral contraceptives, cyclic progestins, ovulation induction agents, and anti-androgenic medications such as aldosterone antagonists, 5α-reductase antagonists, and follicle ornithine decarboxylase inhibitors. Additionally, newer treatments focus on addressing insulin resistance with medications like metformin and thiazolidinediones (rosiglitazone and pioglitazone), as well as using a CYP19 aromatase inhibitor (letrozole) and statins to potentially reduce testosterone levels. These management strategies aim to control symptoms by targeting both glucose-insulin abnormalities and androgen excess.
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