Capryloyl Glycine And Soy Isoflavonoids In Hypertrichosis: An Experimental And Placebo-Controlled Clinical Study

The study investigated a cream with 4% capryloyl glycine and 1% soy isoflavonoids for treating hypertrichosis on the forearms of 12 Caucasian female patients. The cream significantly reduced ornithine decarboxylase 1 (ODC1) activity by 35.1%. After four months, 91.7% of patients using the cream showed improvement, with 58.3% experiencing good efficacy and 41.7% moderate efficacy, while the placebo group showed no improvement. The cream was well-tolerated, with no adverse events and good cosmetic acceptability. The study concluded that the cream effectively reduced hair growth in the tested population, but recommended further trials with more participants to confirm these findings.