Hormonal Treatment Strategies Tailored to Non-Binary Transgender Individuals

May 2020 in “ Journal of Clinical Medicine ”

Carlotta Cocchetti, Jiska Ristori, Alessia Romani, Mario Maggi, Alessandra D. Fisher

cyproterone acetate spironolactone 5α-reductase inhibitors finasteride dutasteride GnRH analogs minoxidil eflornithine antiandrogens male pattern hair loss Propecia Rogaine

TLDR Non-binary transgender individuals need personalized hormonal treatments for better well-being and quality of life.

The document from May 26, 2020, highlights the absence of standardized hormonal treatment protocols for non-binary transgender individuals and underscores the necessity for personalized treatment plans to enhance their psychological well-being and quality of life. It suggests the use of various hormonal and non-hormonal compounds to fulfill the unique requests of non-binary clients, with an emphasis on the importance of clinicians collaborating with individuals to customize treatments that consider both benefits and risks. The review mentions specific dosages for antiandrogens like cyproterone acetate and spironolactone, and discusses the use of 5α-reductase inhibitors such as finasteride and dutasteride for preventing male pattern hair loss in binary AMAB transgender individuals. Additionally, it considers the use of GnRH analogs and non-hormonal compounds like minoxidil and eflornithine for hair growth modulation. The document concludes by stressing the need for more research on the efficacy and safety of these treatments for non-binary individuals.

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Research cited in this study

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research Minoxidil: Mechanisms of Action on Hair Growth

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research Hair Loss in Women: Comprehensive Overview and Treatment Options

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